Anesth Pain Med.  2017 Oct;12(4):335-338. 10.17085/apm.2017.12.4.335.

Experience with reversal of a neuromuscular block with sugammadex in a child with Prader-Willi syndrome: A case report

• Sung TY
• Kang T
• Cho CK
• Kwon HU
• Kang PS
• Jee YS

• KMID: 2405850
• DOI: http://doi.org/10.17085/apm.2017.12.4.335

Abstract

We treated a 4-year-old patient with a genetic disorder, Prader-Willi syndrome, that was accompanied by pulmonary hypertension due to upper airway obstruction. Prader-Willi syndrome is a complex genetic condition characterized by hypotonia, feeding difficulties, poor growth, and delayed development. Hypotonia was the main concern in the anesthetic management of this patient, including the choice of a neuromuscular blocking agent. We report successful induction of anesthesia in this patient with sevoflurane inhalation, remifentanil infusion, and a non-depolarizing muscle relaxant, rocuronium, while following up the status of the neuromuscular block by train-of-four monitoring and reversing the neuromuscular block with sugammadex.

Keyword

Hypotonia; Prader-Willi syndrome; Pulmonary hypertension; Remifentanil; Rocuronium; Sugammadex

MeSH Terms

Airway Obstruction
Anesthesia
Child*
Child, Preschool
Humans
Hypertension, Pulmonary
Inhalation
Muscle Hypotonia
Neuromuscular Blockade*
Neuromuscular Monitoring
Prader-Willi Syndrome*

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