Ann Surg Treat Res.  2018 Jan;94(1):1-7. 10.4174/astr.2018.94.1.1.

Evaluation of a polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam) in a rat wound model

• Lee JW
• Song KY

• KMID: 2405332
• DOI: http://doi.org/10.4174/astr.2018.94.1.1

Abstract

PURPOSE
The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety.
METHODS
Fifty-four male adult Sprague-Dawley rats (weight, 200-250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group): Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared.
RESULTS
All groups showed an effective decrease in wound size. However, the differences between Betafoam and the other dressings were statistically significant on day 14 (P < 0.05). The number of newly generated blood vessels in the Betafoam group was significantly higher than in the gauze, Allevyn-Ag, and Medifoam silver groups (P < 0.001). In the Betafoam group, the proportion of collagen deposition was highest and showed a significantly superior arrangement of collagen fibers compared with the gauze, Allevyn-Ag, Mepilex-Ag, and Medifoam silver groups. The total content of the remaining DNA counts of the exchanged dressings were significantly lower in the Betafoam group than the others.
CONCLUSION
Betafoam is effective in wound healing and provides the best performance amongst the various types of dressing materials in terms of re-epithelialization, angiogenesis, collagen deposition, and tissue invasion.

Keyword

Polyurethane foam; Wound healing; Povidone-iodine; In vivo

MeSH Terms

Adult
Animals
Bandages*
Blood Vessels
Collagen
DNA
Humans
Male
Polyurethanes*
Povidone-Iodine*
Rats*
Rats, Sprague-Dawley
Re-Epithelialization
Silver
Skin
Wound Healing
Wounds and Injuries*
Collagen
DNA
Polyurethanes
Povidone-Iodine
Silver

Figure

• 

  Fig. 1 Full-thickness wound model on the dorsal skin of male adult Sprague-Dawley rats. A 2.5-cm diameter full-thickness circular piece of tissue was excised from the dorsal skin (n = 9 for each group).

• 

  Fig. 2 Temperature (A) and humidity (B) for wound healing (n = 9 for each group).

• 

  Fig. 3 Wound areas at each time point. Gross observation (A) and numerical comparison (B) for each group (n = 9 for each group). *P < 0.05.

• 

  Fig. 4 Histologic analysis of the wound edge and bed. Hematoxylin and eosin staining (×100) (A) and numerical comparison (B) for each group (n = 9 for each group). *P < 0.05.

• 

  Fig. 5 Effects of each dressing material on angiogenesis. Hematoxylin and eosin staining (×200) (A) and numerical comparison (B) for each group (n = 9 for each group). *P < 0.05.

• 

  Fig. 6 Effects of each dressing material on collagen deposition. Masson's trichrome (×200) (A) staining and numerical comparison (B) for each group (n = 9 for each group). *P < 0.05.

• 

  Fig. 7 Amount of residual DNA remaining in each exchanged dressing material (n = 9 for each group).

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