Exp Neurobiol.  2018 Feb;27(1):28-33. 10.5607/en.2018.27.1.28.

The Transient Intermediate Plexiform Layer, a Plexiform Layer-like Structure Temporarily Existing in the Inner Nuclear Layer in Developing Rat Retina

• Park HW
• Kim HL
• Park YS
• Kim IB

• KMID: 2405306
• DOI: http://doi.org/10.5607/en.2018.27.1.28

Abstract

The retina is a highly specialised part of the brain responsible for visual processing. It is well-laminated; three layers containing five different types of neurons are compartmentalised by two synaptic layers. Among the retinal layers, the inner nuclear layer (INL) is composed of horizontal, bipolar, and amacrine cell types. Bipolar cells form one sublayer in the distal half of the IPL, while amacrine cells form another sublayer in the proximal half, without any border-like structure. Here, we report that a plexiform layer-like structure exists temporarily in the border between the bipolar and amacrine sublayers in the INL in the rat retina during retinal development. This transient intermediate plexiform layer (TIPL) appeared at postnatal day (PD) 7 and then disappeared around PD 12. Most apoptotic cells in the INL were found near the TIPL. These results suggest that the TIPL may contribute to the formation of sublayers and the cell number limit in the INL.

Keyword

Apoptosis; Development; Positioning; Retina

MeSH Terms

Amacrine Cells
Animals
Apoptosis
Brain
Cell Count
Neurons
Rats*
Retina*
Retinaldehyde
Retinaldehyde