Gut Liver.
2018 Jan;12(1):67-72. 10.5009/gnl16500.
The Clinical Characteristics and Prognosis of Crohn's Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study
- Affiliations
-
- 1Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea. hands@hanyang.ac.kr
- 2Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 4Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
- 5Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 6Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2404719
- DOI: http://doi.org/10.5009/gnl16500
Abstract
- BACKGROUND/AIMS
We aimed to evaluate the clinical characteristics and prognosis of Crohn's disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort.
METHODS
We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of patients were evaluated according to the presence of proximal small bowel involvement.
RESULTS
Among 1,329 patients with CD for whom complete disease location data were available, 222 patients (16.7%) showed involvement of the proximal small bowel. Compared to patients without proximal small bowel involvement, those with small bowel involvement were more likely to display stricturing behavior (19.8% vs 12.7%, p=0.020). The surgery-free survival of patients who showed proximal small bowel involvement was inferior to that of patients without proximal small bowel involvement (10-year surgery-free survival: 58.4% vs 67.7%, respectively, p < 0.001). Additionally, upper gastrointestinal involvement was more common in patients with proximal small bowel involvement than in those without involvement (odds ratio, 1.643; 95% confidence interval, 1.008 to 2.677).
CONCLUSIONS
Proximal small bowel involvement is a poor prognostic factor for the surgery-free survival of Korean patients with CD. Proximal small bowel involvement should be evaluated in patients with CD for predicting long-term clinical outcomes.
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