Clin Hypertens.  2017 ;23(1):16. 10.1186/s40885-017-0072-2.

A multicenter cohort study of primary hypertension in Korea: study design and interim analysis of the Korean registry of target organ damage in hypertension (KorHR)

• Choi SW
• Han SW
• Ok JS
• Yoo BS
• Shin MS
• Park SH
• Ryu KH

• KMID: 2404101
• DOI: http://doi.org/10.1186/s40885-017-0072-2

Abstract

BACKGROUND
The Korean Registry of Target Organ Damage in Hypertension aims to evaluate the clinical characteristics and prevalence of subclinical target organ damage in Korean hypertensive patients. METHOD: This is a prospective, observational, multicenter cohort study in which 23 university hospitals participated. Since May 2013, we have enrolled 1,318 consecutive hypertensive patients without known cardiovascular disease who met the following inclusion criteria: 1) age older than 30 years and 2) the first visit to the participating hospitals was within the last 5 years.
RESULTS
The mean age was 52 ± 12 years; 62.1% were male, and 41.3% were incident hypertensives. Patients with diabetes mellitus accounted for 7.8% of the population and 43.8% had hyperlipidemia or were on statins at baseline. The mean office blood pressures were 152 ± 20/96 ± 14 mmHg for incident hypertensive patients and 129 ± 13/78 ± 10 mmHg for patients on treatment. Patients with electrocardiographic and echocardiographic left ventricular hypertrophy accounted for 18.9 and 25.6%, respectively. The mean brachial-ankle pulse wave velocity (PWV) was 1564 ± 293 m/s and 19.5% had PWV values of more than 1750 cm/s. Patients with microalbuminuria and chronic kidney disease accounted for 21 and 4%, respectively. The first prescribed class of antihypertensive medications was angiotensin converting enzyme inhibitors in 2.9%, angiotensin receptor blockers (ARBs) in 57.5%, diuretics in 7.6%, calcium channel blockers (CCBs) in 61.0%, beta blockers in 17.3%, and fixed dose combination pill in 27.8%.
CONCLUSION
Our interim analysis shows that subclinical target organ damage in hypertension is considerably present for incident or treated hypertensive patients. CCBs and ARBs were the most commonly prescribed classes of antihypertensive medications and fixed dose combination pills were actively used in Korea. TRIAL REGISTRATION: NCT01861080. Registered 16 May 2013

Keyword

Target organ damage; Hypertension

MeSH Terms

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Calcium Channel Blockers
Cardiovascular Diseases
Cohort Studies*
Diabetes Mellitus
Diuretics
Echocardiography
Electrocardiography
Hospitals, University
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipidemias
Hypertension*
Hypertrophy, Left Ventricular
Korea*
Male
Methods
Prevalence
Prospective Studies
Pulse Wave Analysis
Renal Insufficiency, Chronic
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Calcium Channel Blockers
Diuretics