J Pathol Transl Med.  2018 Jan;52(1):56-60. 10.4132/jptm.2017.04.08.

Colloid Carcinoma of the Uterine Cervix and Its Immunohistochemical Analysis: A Case Report

• Koc N
• Arinkan SA
• Ozbay NO
• Selcuk S

• KMID: 2403259
• DOI: http://doi.org/10.4132/jptm.2017.04.08

Abstract

Colloid carcinoma, which is a very rare tumor of the uterine cervix, is composed of an excessive amount of mucus and a relative paucity of tumoral glandular cells within them. Herein, we report a rare case of colloid carcinoma of the cervix with adenocarcinoma in situ (AIS), intestinal and usual types, and endocervical adenocarcinoma (usual type) components. We also discuss the morphological and immunohistochemical characteristics of this tumor. A 51-year-old woman was referred to our outpatient clinic with the symptom of genital bleeding lasting for 5 months. She had a cervix surrounded by an irregular tumor with a diameter of 5 cm. The colloid carcinoma cells were positive for MUC2, MUC5AC, and cytokeratin (CK) 7, focal positive for CDX2, and negative for MUC6 and CK20. Also, the intestinal type AIS showed a similar staining pattern. Colloid carcinoma cells producing mucin showed an intestinal phenotype and AIS. The intestinal type can be considered as a precursor lesion of colloid carcinoma.

Keyword

Colloid carcinoma; Cervix uteri; Neoplasms

MeSH Terms

Adenocarcinoma
Adenocarcinoma in Situ
Adenocarcinoma, Mucinous*
Ambulatory Care Facilities
Cervix Uteri*
Colloids*
Female
Hemorrhage
Humans
Keratins
Middle Aged
Mucins
Mucus
Phenotype
Colloids
Keratins
Mucins

Figure

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  Fig. 1. Gross appearance of the tumor. The cervix is surrounded by an irregular tumor (arrows), with erosion in the mucosal surface covered by mucinous layer.

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  Fig. 2. Colloid carcinoma component is present in the deep area. Adenocarcinoma in situ (AIS), usual and intestinal types (inset), and endocervical adenocarcinoma (usual type) components are present in the superficial area (A). Colloid carcinoma cells and AIS intestinal type cells (inset) are positive for MUC2(B) and MUC5AC (C) and negative for MUC6 (D).

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