J Korean Soc Laryngol Phoniatr Logoped.  2017 Dec;28(2):144-147. 10.0000/jkslpl.2017.28.2.144.

A Case of Malignant Transformation of Layngeal Mucosa after Inhalation Injury 25 Years Ago

• Lee JY
• Lee G
• Ahn D
• Sohn JH

• KMID: 2402967
• DOI: http://doi.org/10.0000/jkslpl.2017.28.2.144

Abstract

Laryngeal neoplasm is the second most common malignancy of the upper aerodigestive tract. About 85% to 95% of laryngeal malignancies are squamous cell carcinoma that arises from the epithelial lining of the larynx. The exact cause of laryngeal neoplasm is unknown, but certain risk factors can affect the chances of developing it. Chronic inflammation is a mutagen factor confirmed in the carcinogenesis of various tumor. Inhalation injuries cause histopathologic damage to laryngeal mucosa and inflammation change. This long term inflammation may leads to the development of dysplasia and malignant transformation. Recently, we experienced a case of malignant transformation of laryngeal mucosa after inhalation injury patient 25 years ago. Herein, we reported this rare case and review the relevant literature.

Keyword

Burn; Laryngeal neoplasms; Inhalation injury; Malignant transformation

MeSH Terms

Burns
Carcinogenesis
Carcinoma, Squamous Cell
Humans
Inflammation
Inhalation*
Laryngeal Mucosa
Laryngeal Neoplasms
Larynx
Mucous Membrane*
Risk Factors