Clin Exp Emerg Med.
2017 Sep;4(3):160-167. 10.15441/ceem.17.220.
Changes in histopathology and tumor necrosis factor-α levels in the hearts of rats following asphyxial cardiac arrest
- Affiliations
-
- 1Department of Emergency Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea. bonaeboa@naver.com
- 2Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.
- 3Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.
- 4Bio Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Iksan, Korea. hjtae@jbnu.ac.kr
- KMID: 2401245
- DOI: http://doi.org/10.15441/ceem.17.220
Abstract
OBJECTIVE
Post cardiac arrest (CA) syndrome is associated with a low survival rate in patients who initially have return of spontaneous circulation (ROSC) after CA. The aim of this study was to examine the histopathology and inflammatory response in the heart during the post CA syndrome.
METHODS
We induced asphyxial CA in male Sprague-Dawley rats and determined the survival rate of these rats during the post resuscitation phase.
RESULTS
Survival of the rats decreased after CA: 66.7% at 6 hours, 36.7% at 1 day, and 6.7% at 2 days after ROSC following CA. The rats were sacrificed at 6 hours, 12 hours, 1 day, and 2 days after ROSC, and their heart tissues were examined. Histopathological scores increased at 12 hours post CA and afterwards, histopathological changes were not significant. In addition, levels of tumor necrosis factor-α immunoreactivity gradually increased after CA.
CONCLUSION
The survival rate of rats 2 days post CA was very low, even though histopathological and inflammatory changes in the heart were not pronounced in the early stage following CA.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Changes in Histopathology and Tumor Necrosis Factor-αLevels in the Hearts of Rats Following Asphyxial Cardiac Arrest
- Effect of Mild Therapeutic Hypothermia in Comatose Survivors after Asphyxial Cardiac Arrest
- Correlation between Brain Ischemia-Reperfusion Injury and Tumor Necrosis Factor-alpha Following Cardiac Arrest in Rats
- The relationship between low survival and acute increase of tumor necrosis factor α expression in the lung in a rat model of asphyxial cardiac arrest
- Effects of N6-L-phenylisopropyl Adenosine in Rats after Asphyxial Cardiac Arrest
