J Lipid Atheroscler.  2017 Dec;6(2):84-88. 10.12997/jla.2017.6.2.84.

Alteration of Lipid Profiles in Patients with Subclinical Hypothyroidism

• Lee JE
• Jeong SJ
• Lee SJ
• Lee YH
• Lee Y
• Lee SJ
• Kim CH

• KMID: 2401110
• DOI: http://doi.org/10.12997/jla.2017.6.2.84

Abstract

OBJECTIVE
Overt hypothyroidism has been associated with abnormalities of lipid metabolism; however conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (SCH) have been reported. The aim of this study was to assess differences in lipid profile parameters between people with and without SCH in Korean population.
METHODS
Serum lipid parameters of 37 patients with SCH and 44 euthyroid control subjects were evaluated in a retrospective cross-sectional study.
RESULTS
The mean serum triglycerides (TG) level was significantly higher in patients with SCH than in controls (p < 0.05). The mean serum high-density lipoprotein cholesterol (HDL-C) level was significantly lower in patients with SCH than in controls (p < 0.05). When adjusted by age, the odds ratio for the association of HDL-C with SCH was significant at 0.893 (95% confidence interval 0.809-0.986) compared with that of the euthyroid controls. No association with SCH was found with total cholesterol level, low-density lipoprotein cholesterol level or serum thyroid-stimulating hormone level. In addition, the lipid profile did not differ significantly between premenopausal and postmenopausal women.
CONCLUSIONS
We found variations of lipid profiles in patients with SCH, characterized by a significantly lower HDL-C level.

Keyword

Subclinical hypothyroidism; Lipid

MeSH Terms

Cholesterol
Cross-Sectional Studies
Female
Humans
Hypothyroidism*
Lipid Metabolism
Lipoproteins
Odds Ratio
Retrospective Studies
Thyrotropin
Triglycerides
Cholesterol
Lipoproteins
Thyrotropin
Triglycerides

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