Serum lipoprotein(a) and lipid concentrations in patients with subclinical hypothyroidism

Kim, Kyoung Eun; Lee, Ok Hee; Moon, Ji Hyun; Lee, Sang Yeoup; Kim, Yun Jin

Abstract

BACKGROUND
There are no agreement for abnormalities in serum lipid concentrations and lipoprotein(a)(Lp(a)) in patients with subclinical hypothyroidism. But there are no reports for consideration of postmenopausal state and hormone replacement therapy(HRT). Therefore, we analized serum Lp(a) and lipid concentrations in patients with subclinical hypothyroidism considering menopause and HRT and the correlation between serum Lp(a) level and thyroid stimulating hormone(TSH) concentration.
METHODS
We undertook this study in 99 patients with subclinical hypothyroidism(TSH>5uIU/mL) and 297 age and sex matched normal control subjects. They had no abnormalities in liver and renal function, fasting blood glucose and medical and drug histories. We excluded who were recieving HRT. Serum free thyroxine, triiodothyronine , TSH were measured by radioimmune assay using commercial kits, and Lp(a), total cholesterol, TG and HDL by Latex and enzyme method, respectively.
RESULTS
There were no significant differences of serum Lp(a), total cholesterol, LDL, TG, HDL concentrations in patients with subclinical hypthyroidism and control subjects, analyzing after dividing into men, premenopausal and postmenopausal women. In patiens with subclinical hypothyroidism, there was no correlation between serum Lp(a) and TSH concentraions(r=0.06, P>0.05).
CONCLUSION
Considering menopause and HRT, there were no increase in serum Lp(a) and lipid concentrations in subclinical hypothyroidism. There was no correlation between serum Lp(a) and TSH concentration in patients with subclinical hypothyroidism.