J Bone Metab.  2017 Nov;24(4):241-248. 10.11005/jbm.2017.24.4.241.

Prevalence of Osteoporosis in Korean Patients with Chronic Obstructive Pulmonary Disease and Their Health-related Quality of Life According to the Korea National Health and Nutrition Examination Survey 2008–2011

Affiliations
  • 1Department of Internal Medicine, Wonkwang University Sanbon Hospital, Gunpo, Korea.
  • 2Division of Biomedicine & Public Health, Mokwon University, Daejeon, Korea. haeyoungkwon0111@gmail.com

Abstract

BACKGROUND
In this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients.
METHODS
A total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry. HRQOL was assessed using the EuroQOL-5 dimensions (EQ-5D) questionnaire. To identify factors associated with osteoporosis and HRQOL in patients with COPD, multivariate regression analyses was performed.
RESULTS
Of the 1,081 COPD patients, 191 (17.7%) were diagnosed with osteoporosis. There were significant differences in age, sex, smoking status, education level, house income, and body mass index (BMI) between the osteoporotic and non-osteoporotic groups. COPD patients with osteoporosis had significantly lower EQ-5D scores than the controls. In multivariate analyses, older age (odds ratio [OR]=1.10, P < 0.001) was risk factor for osteoporosis. And patients of male sex (OR=0.06, P < 0.001), high house income (OR=0.75, P=0.045), and high BMI (OR=0.74, P < 0.001) were less likely to have osteoporosis. In addition, osteoporosis was associated with poor HRQOL (β=−0.21, P=0.023).
CONCLUSIONS
The prevalence of osteoporosis in COPD patients based on the 2008 to 2011 KNHANES data were relatively lower than that in physician-diagnosed COPD patients. In these COPD patients, older age, female sex, low household income, and low BMI increased the risk for osteoporosis.

Keyword

Bone density; Osteoporosis; Pulmonary disease chronic obstructive; Quality of life

MeSH Terms

Absorptiometry, Photon
Body Mass Index
Bone Density
Education
Family Characteristics
Female
Femur
Femur Neck
Humans
Korea*
Male
Multivariate Analysis
Nutrition Surveys*
Osteoporosis*
Prevalence*
Pulmonary Disease, Chronic Obstructive*
Quality of Life*
Risk Factors
Smoke
Smoking
Spine
Smoke

Figure

  • Fig. 1 Flow chart of the study population. COPD, chronic obstructive pulmonary disease; BMD, body mineral density.

  • Fig. 2 Prevalence of osteoporosis according to the severity of chronic obstructive pulmonary disease. Stage I: forced expiratory volume in 1 second (FEV1)≥80%, stage II: FEV1=50–80%, stage III: FEV1=30–50%, stage IV: FEV1<30% (P=0.860).


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Mihye Jung, Seong Hee Ahn, Seongha Seo, Yongin Cho, Da Hea Seo, So Hun Kim, Seongbin Hong
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