Nucl Med Mol Imaging.  2017 Sep;51(3):227-232. 10.1007/s13139-017-0472-y.

Quantification of Contraction Synchronicity and Contraction Work in Coronary Artery Disease

• Niimi T
• Nanasato M
• Maeda H

• KMID: 2396580
• DOI: http://doi.org/10.1007/s13139-017-0472-y

Abstract

PURPOSE
This study quantified the contraction synchronicity (CS; with 100% representing full synchrony and −100% dyssynchrony) and contraction work (CW, millijoules per centimeter squared; representingmyocardial area) in patients with reduced left ventricular ejection fraction (LVEF) associated with coronary artery disease (CAD).
METHODS
CS, CW and LVEF in 104 subjects (54 CAD patients and 50 control subjects without CAD) were measured using rest electrocardiography-gated single-photon emission computed tomography (ECG SPECT). Contraction amplitude (CA), synchronous contraction index (SCI), and CW were evaluated using the program Quantification of Segmental Function by Solving the Poisson Equation (QSFP) developed in-house.
RESULTS
The mean CA, SCI and CW of 17 segments in the control subjects were 33.8 ± 4.1% (±SD), 96.6 ± 1.4%, and 6.9 ± 1.0 mJ/cm², respectively. In the patients with CAD, the respective values were 26.1 ± 7.3%, 82.1 ± 16.8%, and 5.4 ± 1.6 mJ/cm². In the CAD patients with LVEF <40% (n = 14), the mean CA, SCI,and CW were 17.9 ± 4.0%, 63.0 ± 18.4%, and 3.5 ± 1.1 mJ/cm², respectively. These values were significantly lower than in the control subjects (p < 0.005). Using receiver operating characteristic analysis, values for the area under the curve showing the performance of CA, CS,CWand LVEF in the diagnosis of CAD were 0.81, 0.86, 0.78, and 0.84, respectively.
CONCLUSION
Asynchrony shown using the QSFP is useful for CAD detection.

Keyword

Contraction amplitude; Contraction synchronicity; Contractionwork; Left ventricular ejection fraction; Coronary artery disease

MeSH Terms

Coronary Artery Disease*
Coronary Vessels*
Diagnosis
Humans
ROC Curve
Stroke Volume
Tomography, Emission-Computed