Psychiatry Investig.  2017 Sep;14(5):669-673. 10.4306/pi.2017.14.5.669.

Periodic Limb Movements in Sleep is Associated with Increased Mortality

Affiliations
  • 1Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea. jeongdu@snu.ac.kr
  • 2Department of Biological Basis of Behavior, University of Pennsylvania, PA, USA.

Abstract


OBJECTIVE
To elucidate the association between periodic limb movements in sleep (PLMS) and mortality.
METHODS
Nocturnal polysomnographic recordings of 1,344 subjects obtained from 1995 to 2008 were reviewed. The subjects were divided into four groups based on PLMS and insomnia: reference group (PLMS≤5), insomnia group (PLMS≤5 with insomnia symptoms), 515 group. We searched each subject's Identification Number in the death records from the Statistics of Korea, the national bureau of statistics, to determine deaths in the cohort that occurred prior to December, 2013. Cox-proportional hazard regression and Kaplan-Meier survival curve analyses were used to compare mortality among the four groups.
RESULTS
Hazard ratios (HRs) in the 515 groups were significantly higher than that in the reference group before adjusting for age and gender [HR, 3.37; 95% confidence interval (CI), 1.73-6.55; p<0.001; HR, 5.77; 95% CI, 3.24-10.29; p<0.001]. Only the PLMS>15 group had a higher mortality rate than that in the reference group after adjusting for age, gender, and sleep efficiency (HR, 1.99; 95% CI, 1.06-2.21; p=0.033).
CONCLUSION
These results suggest that PLMS may be associated with increased mortality.

Keyword

Periodic limb movements in sleep; Mortality

MeSH Terms

Cohort Studies
Death Certificates
Extremities*
Korea
Mortality*
Sleep Initiation and Maintenance Disorders
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