Ann Dermatol.  2017 Dec;29(6):796-799. 10.5021/ad.2017.29.6.796.

Therapeutic Effects of a Light Emitting Diode at a Variety of Wavelengths on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

• Cho EA
• Lee YJ
• Ryu YH
• Han JH
• Lee JH
• Park YM

• KMID: 2395193
• DOI: http://doi.org/10.5021/ad.2017.29.6.796

Abstract

No abstract available.

MeSH Terms

Animals
Mice*
Skin*
Therapeutic Uses*
Therapeutic Uses

Figure

• 

  Fig. 1 Clinical and histologic features of DNCB-induced AD-like lesions in NC/Nga mice. (A) Representative images of the ear lesions and ear thickness taken from each group on day 11. (B) Histological features of ear skin (toluidine blue stain, ×200) and number of mast cells in 5 randomly chosen visual fields at ×400 magnification. Data are expressed in box-and-whisker plots that represent the median, the lower and upper quartile and the minimum to the maximum values. DNCB: 2,4-dinitrochlorobenzene, AD: atopic dermatitis. *p<0.05 compared with the non-irradiated group (DNCB only).

• 

  Fig. 2 Effects of light-emitting diode (LED) irradiation on IL-4, IFN-γ, and IgE production in DNCB-induced AD-like lesions of NC/Nga mice. (A) The expression of IL-4 and IFN-γ mRNA in ear skin lesions and serum IL-4 and IFN-γ levels, and (B) the serum IgE levels. Data are expressed in Box-and-Whisker plots that represent the median, the lower and upper quartile, and the minimum to the maximum values. IL: interleukin, IFN: interferon, IgE: immunoglobulin E, DNCB: 2,4-dinitrochlorobenzene, AD: atopic dermatitis. *p<0.05 compared with the non-irradiated group (DNCB only).

Reference

1. Cui HS, Ahn IS, Byun YS, Yang YS, Kim JH, Chung BY, et al. Dietary pattern and nutrient intake of korean children with atopic dermatitis. Ann Dermatol. 2014; 26:570–575.

2. Schmitt J, von Kobyletzki L, Svensson A, Apfelbacher C. Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials. Br J Dermatol. 2011; 164:415–428.

3. von Kobyletzki G, Pieck C, Hoffmann K, Freitag M, Altmeyer P. Medium-dose UVA1 cold-light phototherapy in the treatment of severe atopic dermatitis. J Am Acad Dermatol. 1999; 41:931–937.

4. Gambichler T, Othlinghaus N, Tomi NS, Holland-Letz T, Boms S, Skrygan M, et al. Medium-dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: a randomized crossover study. Br J Dermatol. 2009; 160:652–658.

5. Pavlovsky M, Baum S, Shpiro D, Pavlovsky L, Pavlotsky F. Narrow band UVB: is it effective and safe for paediatric psoriasis and atopic dermatitis? J Eur Acad Dermatol Venereol. 2011; 25:727–729.

6. Barolet D. Light-emitting diodes (LEDs) in dermatology. Semin Cutan Med Surg. 2008; 27:227–238.

7. Yeh NG, Wu CH, Cheng TC. Light-emitting diodes-Their potential in biomedical applications. Renew Sustain Energy Rev. 2010; 14:2161–2166.

8. Morita H, Kohno J, Tanaka S, Kitano Y, Sagami S. Clinical application of GaAlAs 830 nm diode laser for atopic dermatitis. Laser Ther. 1993; 5:75–78.

9. Cheong KA, Kim CH, Choi Y, Park CD, Lee AY. Irradiation of light emitting diode at 850nm inhibits T cell-induced cytokine expression. J Dermatol Sci. 2012; 65:27–37.

10. Jung KE, Lee YJ, Ryu YH, Kim JE, Kim HS, Kim BJ, et al. Effects of topically applied rapamycin and mycophenolic acid on TNCB-induced atopic dermatitis-like skin lesions in NC/Nga mice. Int Immunopharmacol. 2015; 26:432–438.