Korean J Vet Res.  2017 Sep;57(3):181-187. 10.14405/kjvr.2017.57.3.181.

Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats

• Jin JY
• Park EH
• Jeon YA
• Lee YJ

• KMID: 2394909
• DOI: http://doi.org/10.14405/kjvr.2017.57.3.181

Abstract

Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10 or 50 mg/kg/day) or amlodipine besylate (Am; 10 mg/kg/day) orally. Hypertension results in injury to several organs and can produce a significant increase in malondialdehyde (MDA) content as a result of lipid peroxidation and endothelial dysfunction. In this study, oral administration of AE and Am significantly reduced systolic blood pressure, organ weight index, and MDA content in tissues but increased significantly the plasma nitrite and nitrate concentrations. The endothelium-dependent relaxant activities of acetylcholine (10⁻¹â°-10⁻³ M) in norepinephrine (NE)-precontracted aorta were increased in AE- and Am-treated rats. Particularly strong endothelium-dependent relaxant activities were observed in AE-treated (50 mg/kg) rats. The endothelium-independent relaxant activities of sodium nitroprusside (10⁻¹â°-10⁻³ M) in NE-precontracted aorta were not changed. The results of this study suggest that AE has both antihypertensive and end-organ protective effects in SHR.

Keyword

Aralia elata; hypertension; lipid peroxidation; nitic oxide

MeSH Terms

Acetylcholine
Administration, Oral
Amlodipine
Animals
Aorta
Aralia*
Blood Pressure
Ethanol*
Hypertension
Lipid Peroxidation
Malondialdehyde
Nitroprusside
Norepinephrine
Organ Size
Plasma
Rats
Rats, Inbred SHR*
Acetylcholine
Amlodipine
Ethanol
Malondialdehyde
Nitroprusside
Norepinephrine