Obstet Gynecol Sci.  2017 Sep;60(5):481-484. 10.5468/ogs.2017.60.5.481.

Metastatic uterine cancer looking as cervical fibroid in recurrent breast cancer woman: a case report

• Seo SY
• Shin JY
• Ji YI

• KMID: 2393850
• DOI: http://doi.org/10.5468/ogs.2017.60.5.481

Abstract

Metastasis to the female genital tract from extragenital primary cancer is uncommon. In this case, a 46-year-old woman was diagnosed with invasive lobular carcinoma of the left breast in 2011. She had left breast conserving surgery, chemotherapy, radiation, and hormonal therapy (gosereline and tamoxifen). However, she developed menorrhagia after interruption of hormonal therapy and incidentally, the ultrasonogram of her pelvis showed a solid, large mass in the cervix. It looked like leiomyoma. Because of massive vaginal bleeding requiring multiple blood transfusions, she underwent total hysterectomy with bilateral salpingo-oophorectomy. Unexpectedly, however, histopathological examination revealed metastatic carcinoma, consistent with breast origin.The metastatic tumor involved the uterine corpus with spreading to the endocervix, left ovary, and multiple lymphovascular invasion was present. We described the rarity and risk of metastatic uterine cancer in patient with history of malignant tumor treatment.

Keyword

Breast cancer; Cervical neoplasms; Hysterectomy; Metastasis; Menorrhagia

MeSH Terms

Blood Transfusion
Breast Neoplasms*
Breast*
Carcinoma, Lobular
Cervix Uteri
Drug Therapy
Female
Humans
Hysterectomy
Leiomyoma*
Mastectomy, Segmental
Menorrhagia
Middle Aged
Neoplasm Metastasis
Ovary
Pelvis
Ultrasonography
Uterine Cervical Neoplasms
Uterine Hemorrhage
Uterine Neoplasms*

Figure

• 

  Fig. 1 (A) Vaginal ultrasonography showing a tumor of the cervix (uteri, 3.4 cm in diameter). (B) The cervix appears as a large, cervical leiomyoma (8.7 cm in 2017).

• 

  Fig. 2 (A) The cut surface of the bisected uterus in the direction from anterior to posterior shows a well demarcated, solid, mass-like lesion; the lesion is yellow, it contains necrotic focus (arrow). (B) Tumor cells lack cohesion and appear individually dispersed through a collagenous stroma, and they occasionally have a signet-ring cell appearance with intracytoplasmic mucin.

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