Obstet Gynecol Sci.  2017 Sep;60(5):433-439. 10.5468/ogs.2017.60.5.433.

The efficacy and safety of pegylated liposomal doxorubicin monotherapy and combination therapy with carboplatin in Korean patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer: a single-institution experience

Affiliations
  • 1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. amcymkim@gmail.com

Abstract


OBJECTIVE
This study aimed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) with or without carboplatin in Korean patients with recurrent ovarian cancer (ROC), fallopian tube, or primary peritoneal cancer.
METHODS
This retrospective study included 52 patients with ROC, fallopian tube, or primary peritoneal cancer who received PLD (50 mg/m²) between 1(st) December 2014 and 31(th) July 2016.
RESULTS
The mean number of chemotherapy cycles was 3.8 (range, 2 to 9) in the PLD monotherapy group and 7 (range, 2 to 13) in the PLD combined with carboplatin (PLD-C) group. In overall response rates and clinical beneficial rates, PLD monotherapy group shows 5.0% and 17.5%, and PLD-C group shows 33.3% and 75.0%. The mean progression-free survival (PFS) was 5 and 13 months in the PLD monotherapy and PLD-C groups, respectively. At 6 months after treatment initiation, absence of disease progression was confirmed in 6 (15%) and 10 (83.3%) patients in the PLD monotherapy and PLD-C groups. Hematological adverse events (e.g., neutropenia and thrombocytopenia) were more common in the PLD-C group (P<0.001, P=0.004). The incidence of anemia and non-hematological adverse events, including mucositis, hand-foot syndrome, and allergic reactions, was similar in both groups.
CONCLUSION
This study demonstrated the efficacy and safety of PLD monotherapy and PLD-C combination in Korean patients with ROC. This study would be helpful to consider the degree of worry about side effects and treatment expectations after treatment. Further retrospective studies with larger samples are required to confirm the efficacy of PLD monotherapy in Asian patients with platinum-resistant ROC.

Keyword

Liposomal doxorubicin; Drug therapy; Hand-foot syndrome

MeSH Terms

Anemia
Asian Continental Ancestry Group
Carboplatin*
Disease Progression
Disease-Free Survival
Doxorubicin*
Drug Therapy
Fallopian Tubes*
Female
Hand-Foot Syndrome
Humans
Hypersensitivity
Incidence
Mucositis
Neutropenia
Ovarian Neoplasms
Retrospective Studies
Carboplatin
Doxorubicin

Figure

  • Fig. 1 PFS in each group. PFS, progression-free survival; PLD, pegylated liposomal doxorubicin; PLD-C, pegylated liposomal doxorubicin combined with carboplatin.


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