Nat Prod Sci.  2017 Sep;23(3):213-216. 10.20307/nps.2017.23.3.213.

A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots

• Park SY
• Lee N
• Lee S
• Kim MJ
• Chun W
• Kim HP
• Yang HJ
• Lee HS
• Kwon Y

• KMID: 2393803
• DOI: http://doi.org/10.20307/nps.2017.23.3.213

Abstract

Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the ICâ‚…â‚€ values of 10.2, 18.1, 21.5 and 22.9 µM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.

Keyword

Heracleum moellendorffii; Angular furanocoumarins; (3S, 4R)-3; 4-epoxypimpinellin; Acetylcholinesterase inhibition

MeSH Terms

Acetylcholinesterase
Cholinesterase Inhibitors
Coumarins
Heracleum*
Methods
Plants
Acetylcholinesterase
Cholinesterase Inhibitors
Coumarins

Figure

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  Fig. 1. Structures of 1 – 4.

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  Fig. 2. Important HMBC correlations of 4.

Reference

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