J Korean Ophthalmol Soc.  2017 Oct;58(10):1160-1168. 10.3341/jkos.2017.58.10.1160.

Retinal Nerve Fiber Layer Thickness Measurement Using Swept Source Optical Coherence Tomography in Healthy Korean

• Choi SH
• Ohn YH
• Park KH

• KMID: 2393168
• DOI: http://doi.org/10.3341/jkos.2017.58.10.1160

Abstract

PURPOSE
To investigate retinal nerve fiber layer (RNFL) thickness using swept source (SS)-optical coherence tomography (OCT) in healthy Koreans and to evaluate the effects of age on the distributional variability of thickness.
METHODS
We performed a retrospective review of 309 normal eyes presenting for examination of peripapillary nerve fiber layer thickness measured by SS-OCT (DRI OCT-1, Atlantis SS-OCT, Topcon, Tokyo, Japan) from July 2014 to February 2016. The patients were between the ages of 20 and 79 without systemic or ocular disease. The patients were divided into 3 age groups of 20 to 39 years (85 eyes), 40 to 59 years (140 eyes), and 60 to 79 years (84 eyes). The groups were matched based on average RNFL thickness and quadrant and 12 o'clock position RNFL thickness.
RESULTS
The average RNFL thickness of the inferior quadrant was the thickest of the layers and revealed a bimodal distribution. In the three groups, the thicknesses of the average RNFL, quadrant, and 12 o'clock RNFL decreased with age. There was significant difference in the measurements (p < 0.05) of quadrant RNFL thickness except that in the nasal quadrant (p = 0.068).
CONCLUSIONS
The thickness of the circumpapillary retinal nerve fiber layer measured by SS-OCT differs according to age and analysis of normal values by age can be useful in the diagnosis of disease.

Keyword

Korean; Retinal nerve fiber layer thickness; Swept source optical coherence tomography

MeSH Terms

Diagnosis
Humans
Nerve Fibers*
Reference Values
Retinaldehyde*
Retrospective Studies
Tomography, Optical Coherence*
Retinaldehyde

Figure

• 

  Figure 1 Scatterplot of mean and 4 quadrant retinal nerve fiver layer (RNFL) thickness according to age. (A-E) All graphs represent a decreasing tendency of thickness by aging. CI = confidence interval.

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  Figure 2 Distribution of Retinal nerve fiber layer (RNFL) thickness according to group. This schimatized graph represent the it is thinner in the older age group.

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  Figure 3 Scatterplot of 12 clock-hour sectors of retinal nerve fiber layer thickness (RNFL) according to age. (A-L) All graphs represent a decreasing tendency of thickness by aging. CI = confidence interval.

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  Figure 4 Distribution of retinal nerve fiber layer thickness (RNFL) thickness according to age (group by 10's). This schimatized graph represent the it is thinner in the older age group.

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