J Korean Ophthalmol Soc.  2016 Jun;57(6):941-950. 10.3341/jkos.2016.57.6.941.

Diagnostic Ability of Macular Ganglion Cell Layer Measurements in Glaucoma Using Swept Source Optical Coherence Tomography

• Lee ES
• Chang JH
• Park TK
• Ohn YH
• Park KH

• KMID: 2290497
• DOI: http://doi.org/10.3341/jkos.2016.57.6.941

Abstract

PURPOSE
To evaluate diagnostic ability of macular ganglion cell complex (mGCC), macular ganglion cell inner plexiform layer (mGCIPL) measurements in glaucoma using swept source deep range imaging optical coherence tomography (DRI OCT-1, Topcon Co., Tokyo, Japan).
METHODS
From August of 2014 to July of 2015, 109 eyes of 109 subjects were assessed for the average thickness and sectional thickness of both mGCC and mGCIPL to determine whether there exists any significant difference among advanced stage glaucoma group, early stage glaucoma group and normal group in Swept source OCT. Comparisons were also made between the above measurements and circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements in their diagnostic accuracy, sensitivity, and specificity.
RESULTS
The diagnostic ability of mGCC based-mean thickness value (area under the curve [AUC] = 0.78/0.99) in detecting early stage glaucoma group as well as advanced stage group was not significantly different from that of cpRNFL thickness measurement. However, there was a significant difference in thickness between mGCIPL (AUC = 0.70) and cpRNFL in early stage glaucoma groups (p = 0.018). The sensitivities and specificities of mGCC were 0.95/0.97, and those of mGCIPL were 0.92/0.97, respectively.
CONCLUSIONS
The two swept source OCT based methods measuring retinal ganglion cell layer thickness appeared to have a good diagnostic accuracy, high sensitivity and specificity in detecting glaucomatous eyes. Nevertheless, of the two methods, mGCC thickness measurement was more efficient in detecting early glaucomatous changes.

Keyword

Glaucoma; Macular ganglion cell and inner plexiform layer; Macular ganglion cell complex; Swept source optical coherence tomography

MeSH Terms

Ganglion Cysts*
Glaucoma*
Nerve Fibers
Retinal Ganglion Cells
Retinaldehyde
Sensitivity and Specificity
Tomography, Optical Coherence*
Retinaldehyde

Figure

• 

  Figure 1. Macular and optic nerve cube scan using deep range imaging swept source optic coherence tomography (DRI OCT-1; Topcon Corp., Tokyo, Japan). (A) Macular ganglion cell layer and inner plexiform layer (mGCIPL), (B) macular ganglion cell complex (mGCC), (C) circumpapillary retinal nerve fiber layer (cpRNFL).

• 

  Figure 2. Comparison of area under the curve (AUC) of retinal nerve fiber layer (RNFL), macular ganglion cell inner plexiform layer (mGCIPL) and macular ganglion cell complex (mGCC) for distinguishing glaucoma from normal group. (A) Receiver operating characteristics (ROC) curve for detection of early glaucoma, (B) curve for detection of advanced glaucoma. p-values for comparing the AUCs were calculated by Delong's method. cpRNFL = circumpapilary retinal nerve fiber layer; AVG = average.

Reference

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