J Obes Metab Syndr.
2017 Sep;26(3):188-196. 10.7570/jomes.2017.26.3.188.
Association between Serum Dipeptidyl Peptidase-4 Concentration and Obesity-related Factors in Health Screen Examinees
- Affiliations
-
- 1Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. mdkmk@dsmc.or.kr
- 2Institute for Cancer Research, Keimyung University, Daegu, Korea.
- 3Department of Food Science and Nutrition, Graduate School, Keimyung University, Daegu, Korea.
- KMID: 2392944
- DOI: http://doi.org/10.7570/jomes.2017.26.3.188
Abstract
- BACKGROUND
Dipeptidyl peptidase-4 (DPP-4) is an aminopeptidase that inhibits the enzymatic degradation of glucagon-like peptide-1, glucose-dependent insulinotropic polypeptides, neuropeptides, and various chemokines. Recent studies reported that serum DPP-4 concentration is correlated with clinical parameters of obesity. However, research on these correlations has never been conducted in Korea. Therefore, we investigated the relationship between serum DPP-4 concentration and various clinical parameters of obesity in the Korean population.
METHODS
Patients who visited the Health Promotion Center at Keimyung University Dongsan Medical Center for a regular medical examination between January 2013 and March 2013 and consented to participate in this study were included. We measured and analyzed parameters of obesity. In addition, serum DPP-4 concentration was determined using an enzyme-linked immunosorbent assay kit.
RESULTS
Serum DPP-4 concentration was positively correlated with lean body mass, total cholesterol level, and creatinine level. Serum DPP-4 concentration was higher in the obese group than in the normal body mass index (BMI) group. No significant difference in serum DPP-4 concentration was found between the metabolically healthy group and metabolically unhealthy group.
CONCLUSION
Serum DPP-4 concentration was higher in the obesity group than in the normal BMI group, which was associated with obesity-related factors.
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