Diabetes Metab J.  2017 Jun;41(3):195-204. 10.4093/dmj.2017.41.3.195.

Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes

Affiliations
  • 1Department of Internal Medicine, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt. mervat2040@yahoo.com
  • 2Department of Clinical Pathology, Mansoura University Faculty of Medicine, Mansoura, Egypt.
  • 3Department of Cardiology, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.

Abstract

BACKGROUND
Low circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes.
METHODS
This cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed.
RESULTS
Prolactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women.
CONCLUSION
In prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes.

Keyword

Cardiac remodeling; Gender; Prediabetes; Prolactin

MeSH Terms

Adult
Blood Glucose
Diabetes Mellitus, Type 2
Echocardiography
Female
Homeostasis
Humans
Hypertrophy, Left Ventricular
Insulin Resistance
Leukocytes
Male
Prediabetic State*
Prolactin*
Prolactin

Figure

  • Fig. 1 Concentric left ventricular hypertrophy by echocardiography. IVSd, inter-ventricular septum diameter; LVIDd, diastolic left ventricular internal diameter; LVPWd, left ventricular posterior wall diameter; IVSs, systolic inter-ventricular septum; LVIDs, systolic left ventricular internal diameter; LVPWs, systolic left vetricular posterior wall thickness; HR, heart rate; EF, ejection fraction; FS, fraction shortening.


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