Allergy Asthma Respir Dis.  2017 Mar;5(2):117-120. 10.4168/aard.2017.5.2.117.

Successful desensitization of a patient with albumin hypersensitivity

• Jung SY
• Choi YJ
• Lee SH
• Kang HR
• Suh DI

• KMID: 2392384
• DOI: http://doi.org/10.4168/aard.2017.5.2.117

Abstract

There have been few cases of albumin hypersensitivity reported, and there is limited information on this condition. When a patient is anaphylactic to a certain drug and no alternative drug is available to treat the underlying condition, desensitization is a reasonable option and can be performed successfully to treat the patient. A standard 12-step, 3-solution rapid desensitization protocol allows the safe readministration of a medication after certain types of immediate hypersensitivity. However, we demonstrated that a new 10-step, 1-solution desensitization protocol using antihistamine and leukotriene receptor antagonist as premedications, which was effective and safe in a patient with hypersensitivity. We report a 13-year-old boy with Gorham-stout syndrome who was presented with newly acquired albumin anaphylaxis and successfully treated with the 10-step rapid drug desensitization protocol.

Keyword

Drug hypersensitivity syndrome; Anaphylaxis; Immunologic desensitization

MeSH Terms

Adolescent
Anaphylaxis
Desensitization, Immunologic
Drug Hypersensitivity Syndrome
Humans
Hypersensitivity*
Hypersensitivity, Immediate
Male
Premedication
Receptors, Leukotriene
Receptors, Leukotriene

Figure

• 

  Fig. 1 Serial X-ray images show the gradual increase in the pleural fluid of both lung fields in 2010 (A), in 2012 (B), in February 2015 (C), and in December 2015 (D).

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  Fig. 2 Hypotension and desaturation occurred after albumin injections, however, vanished after desensitization. LTRA, Leukotriene receptor antagonist. ♦ indicates symptoms of flushing or rash.

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