J Vet Sci.  2012 Dec;13(4):433-436.

Plasma free amino acid profiles of canine mammary gland tumors

  • 1School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan. tosaki@muses.tottori-u.ac.jp


The purpose of this study was to elucidate the relationship between plasma free amino acid (PFAA) levels and the clinical stages of mammary gland tumors (MGT) in dogs. PFAA levels in canines with malignant mammary tumors were decreased compared to those of healthy animals. The levels of aspartate and ornithine, in the dogs with tumor metastasis were significantly decreased when compared to those of dogs that did not have metastases. Results of this study indicate that PFAA levels could be a risk factor or biomarker for canine MGT metastasis.


dog; mammary gland tumor; plasma free amino acid

MeSH Terms

Aspartic Acid
Mammary Glands, Human
Neoplasm Metastasis
Risk Factors


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