Genomics Inform.
2014 Dec;12(4):261-267. 10.5808/GI.2014.12.4.261.
Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
- Affiliations
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- 1Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Korea. khs307@pusan.ac.kr
- 2Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
- 3TBI, Theragen BiO Institute, TheragenEtex, Suwon 443-270, Korea.
- 4Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.
- KMID: 2391506
- DOI: http://doi.org/10.5808/GI.2014.12.4.261
Abstract
- MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs.
