Korean J Blood Transfus.
2017 Aug;28(2):170-176. 10.17945/kjbt.2017.28.2.170.
Revisiting the Pre-transfusion Test: A Case of Acute Hemolytic Transfusion Reaction due to Multiple Alloantibodies of Anti-E, Anti-c, Anti-Jk(b)
- Affiliations
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- 1Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. progreen@dau.ac.kr
- 2Department of Intensive Care Medicine and Neurology, Dong-A University Hospital, Busan, Korea.
- 3Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
- KMID: 2391235
- DOI: http://doi.org/10.17945/kjbt.2017.28.2.170
Abstract
- We report a case of acute hemolytic transfusion reaction due to multiple alloantibodies. A 41-year-old male with multiple histories of transfusion was admitted for jaundice and oliguria after receiving two units of red blood cells in a local clinic. He showed acute renal failure and disseminated intravascular coagulation. Direct Coombs test was negative and antibody screening test showed strong positive results. Anti-E, anti-c, and anti-Jk(b) antibodies were identified in two panels of unexpected antibody assays. Acute hemolytic transfusion was diagnosed, and he was discharged after 1 month of supportive treatment. Unexpected antibody detection tests, including the antiglobulin phase, should be performed to prevent adverse transfusion reactions by unexpected antibodies. Better precision and quality control are necessary when performing pre-transfusion tests.
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