Korean J Blood Transfus.  2017 Aug;28(2):113-125. 10.17945/kjbt.2017.28.2.113.

The Current Global Status and Production Trends of Plasma Fractionation

Affiliations
  • 1Department of Laboratory Medicine, Seonam University College of Medicine Myongji Hospital, Goyang, Korea. kimmunj@gmail.com
  • 2College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.

Abstract

The demand for medicinal products derived from plasmas are increasing on a global scale. In particular, the demand for intravenous immunoglobulin has continuously been increasing. The increase in the capacity of commercial plasma fractionators is prominent compared with that of non-profit plasma fractionators; thus, the percentage of plasmapheresis has increased with respect to that of plasma from whole blood. The inequality between the consumption of plasma-derived medicinal products and supply of raw plasma among developed countries and developing countries is due to the direct, proportional relationship between the consumption of plasma-derived medicinal products and the size of gross domestic products. Each country decides on its own system to achieve a stable supply of plasma-derived medicinal products. Although domestic production is an ideal option, many countries establish contracts with plasma fractionators. Owing to a great ripple effect, safety measures are increasingly applied, so detailed review should be conducted with consideration given to the cost-effectiveness and the situation unique to each country.

Keyword

Plasma-derived medicinal products; Plasma fractionation; Immunoglobulin; Coagulation factor; Albumin

MeSH Terms

Blood Coagulation Factors
Developed Countries
Developing Countries
Gross Domestic Product
Immunoglobulins
Plasma*
Plasmapheresis
Socioeconomic Factors
Blood Coagulation Factors
Immunoglobulins
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