World J Mens Health.
2025 Apr;43(2):359-375. 10.5534/wjmh.240086.
Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations
- Hashimi MA1,2,3
- Pinggera GM3,4
- Mostafa T3,5
- Rambhatla A3,6
- Hamoda T3,7,8
- Shah R3,9
- Chung E3,10
- Harraz A3,11,12,13
- Arafa M3,5,14,15
- Toprak T3,16
- Raheem O3,17
- Giulioni C3,18
- Birowo P3,19
- Boeri L3,20
- Jassim Y3,21
- Kothari P3,22
- Vishwakarma R3,9
- Sahin B3,23
- Atmoko W3,19
- Gamidov S3,24
- Rojas-Cruz C3,25
- Katz D3,26,27,28
- Fregonesi A3,29
- Gherabi N3,30
- Zini A3,31
- Ho CCK3,32
- Al-Marhoon MS3,33
- Martinez M3,34
- Russo GI3,35
- Rashed A3,36
- Busetto GM3,37
- Ko E3,38
- Park HJ3,39,40
- Cayan S3,41
- Saleh R3,42
- Rajmil O3,43
- Kim DS3,44
- Colpi G3,45
- Smith R3,46
- Ragab M3,47
- Kadioglu A3,48
- Nguyen Q3,49,50
- Bocu K3,51
- El-Sakka A3,52
- Thomas C3,53
- Alnajjar HM3,54
- Alipour H3,55
- Agarwal A
3,56
- Affiliations
-
- 1Department of Urology, Burjeel Hospital, Abu Dhabi, UAE
- 2Department of Clinical Urology, College of Medicine and Health Science, Khalifa University, Abu Dhabi, UAE
- 3Global Andrology Forum, Moreland Hills, OH, USA
- 4Department of Urology, Innsbruck Medical University, Innsbruck, Austria
- 5Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt
- 6Department of Urology, Henry Ford Health System, Vattikuti Urology Institute, Detroit, MI USA
- 7Department of Urology, King Abdulaziz University, Jeddah, Saudi Arabia
- 8Department of Urology, Faculty of Medicine, Minia University, Minia, Egypt
- 9Division of Andrology, Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India
- 10Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia
- 11Department of Urology, Mansoura University Urology and Nephrology Center, Mansoura, Egypt
- 12Department of Surgery, Urology Unit, Farwaniya Hospital, Farwaniya, Kuwait
- 13Department of Urology, Sabah Al Ahmad Urology Center, Kuwait City, Kuwait
- 14Department of Urology, Hamad Medical Corporation, Doha, Qatar
- 15Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar
- 16Department of Urology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye
- 17Section of Urology, University of Chicago, Chicago, IL, USA
- 18Department of Urology, Polytechnic University of Marche Region, Ancona, Italy
- 19Department of Urology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
- 20Department of Urology, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy
- 21Department of Urology, Canadian Specialist Hospital, Dubai, UAE
- 22Department of Urology, B.Y.L Nair Ch Hospital, Topiwala National Medical College, Mumbai, India
- 23Department of Urology, Marmara University School of Medicine, Istanbul, Türkiye
- 24Deparment of Urology, Kulakov National Medical Research, Moscow, Russia
- 25Department of Urology, University Hospital of Rostock, Rostock, Germany
- 26Department of Urology, Men’s Health Melbourne, Victoria, Australia
- 27Department of Surgery, Western Precinct, University of Melbourne, Victoria, Australia
- 28Department of Urology, Western Health, Victoria, Australia
- 29Discipline of Urology, Department of Surgery, School of Medicine, Universida de Estadual de Campina, Sao Paolo, Brazil
- 30Department of Medicine, University of Algiers 1, Algiers, Algeria
- 31Department of Surgery, McGill University, Montreal, QC, Canada
- 32Department of Surgery, School of Medicine, Taylor’s University, Selangor, Malaysia
- 33Division of Urology, Department of Surgery, Sultan Qaboos University, Muscat, Oman
- 34Section of Urology, Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines
- 35Urology Section, University of Catania, Catania, Italy
- 36Department of Urology and Andrology, October 6th University, Cairo, Egypt
- 37Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy
- 38Department of Urology, Kaiser Permanente, Fontana, CA, USA
- 39Department of Urology, Pusan National University School of Medicine, Busan
- 40Medical Research Institute, Pusan National University Hospital, Busan, Korea
- 41Department of Urology, University of Mersin School of Medicine, Mersin, Türkiye
- 42Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt
- 43Department of Andrology, Fundacio Puigvert, Barcelona, Spain
- 44Department of Urology, CHA Gangnam Medical Center, CHA University, Seoul, Korea
- 45Andrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland
- 46Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA
- 47Urology Department, Tanta University, Tanta, Egypt
- 48Section of Andrology, Department of Urology, Istanbul School of Medicine, Istanbul, Türkiye
- 49Center for Andrology and Sexual Medicine, Viet Duc University Hospital, Hanoi, Vietnam
- 50Department of Urology, Andrology and Sexual Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam
- 51Department of Urology, Niğde Omer Halisdemir University, Niğde, Türkiye
- 52Department of Urology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
- 53Department of Urology, General Hospital of Corinth, Corinthia, Greece
- 54Department of Urology, University College London Hospital, London, UK
- 55Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
- 56Cleveland Clinic Foundation, Cleveland, OH, USA
- KMID: 2565976
- DOI: http://doi.org/10.5534/wjmh.240086
Abstract
- Purpose
This study aimed to examine current global practices in regenerative therapy (RT) for erectile dysfunction (ED) and to establish expert recommendations for its use, addressing the current lack of solid evidence and standardized guidelines.
Materials and Methods
A 39-question survey was developed by senior Global Andrology Forum (GAF) experts to comprehensively cover clinical aspects of RT. This was distributed globally via a secure online Google Form to ED specialists through the GAF website, international professional societies, and social media, the responses were analyzed and presented for frequencies as percentages. Consensus on expert recommendations for RT use was achieved using the Delphi method.
Results
Out of 479 respondents from 62 countries, a third reported using RT for ED. The most popular treatment was low-intensity shock wave therapy (54.6%), followed by platelet-rich plasma (24.5%) and their combination (14.7%), with stem cell therapy being the least used (3.7%). The primary indication for RT was the refractory or adverse effects of PDE5 inhibitors, with the best effectiveness reported in middle-aged and mild-to-moderate ED patients. Respondents were confident about its overall safety, with a significant number expressing interest in RT’s future use, despite pending guidelines support.
Conclusions
This inaugural global survey reveals a growing use of RT in ED treatment, showcasing its diverse clinical applications and potential for future widespread adoption. However, the lack of comprehensive evidence and clear guidelines requires further research to standardize RT practices in ED treatment.
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