Lab Anim Res.  2017 Sep;33(3):251-255. 10.5625/lar.2017.33.3.251.

Safety of 8-weeks oral administration of Arctium lappa L.

  • 1College of Oriental Medicine, Dongshin University, Naju, Korea.,
  • 2Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Korea.
  • 3College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.


Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient may have a history of use as a culinary material, changes in the environment over time suggest that the acceptable maximum intake each of food/culinary material should be regularly evaluated. Arctium lappa L. has been used as a culinary material for many centuries in Korea and Japan and some recent studies have reported related therapeutic effects. However, there are no reports on the safety of repeated oral administration. In this study, we evaluated the safety of a 8-weeks repeated oral intake of A. lappa. We concluded that treatment with <250 mg/kg A. lappa, which was within the safety range, resulted in body weight decrease and blood glucose suppression.


Arctium lappa L.; safety of repeated oral intake (administration); body weight decrement; blood glucose suppression

MeSH Terms

Administration, Oral*
Blood Glucose
Body Weight
Public Health
Recommended Dietary Allowances
Therapeutic Uses
World Health Organization
Blood Glucose
Therapeutic Uses


  • Figure 1 The body weight changes over 8-weeks. Con, normal diet treatment group (control group); 60% fat diet, 60%-fat diet treatment group; 50 mg/kg Arctium lappa L., 50 mg/kg Arctium lappa L. treatment with 60%-fat diet group; 250 mg/kg Arctium lappa L., 250 mg/kg Arctium lappa L. treatment with 60%-fat diet group. The dots and the bars indicate the average and standard deviation.

  • Figure 2 Histopathological images from rats in each group. A, photographs of the lung; B, photographs of the heart; C, photographs of the kidney; D, photographs of the brain; E, photographs of the spleen. A, normal diet treatment group (control group); B, 60%-fat diet treatment group; C, 50 mg/kg Arctium lappa L. treatment with 60%-fat diet; D, 250 mg/kg Arctium lappa L. treatment with 60%-fat diet. Scale bar: 100 µm


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