Korean Circ J.  1996 Apr;26(2):578-585. 10.4070/kcj.1996.26.2.578.

A Clinical Study on Antihypertensive Effects and Safety of Benidipine

• Hur SC
• Chun DS
• Lee KH
• Cha H

• KMID: 2228947
• DOI: http://doi.org/10.4070/kcj.1996.26.2.578

Abstract

BACKGROUND
This study was designed to evaluate the antihypertensive efficacy and safety of benidipine hydrochloride, a Ca(++)-channel blocker, in patients with mild to moderate essential hypertension.
METHODS
Benidipine was administered in 2-8mg once daily for 10 weeks in 16 hypertensive patients with diastolic blood pressure over 95mmHg and adverse effects were checked every two weeks after benidipine administration. Chest X-ray, ECG, funduscopy, and laboratory examination were performed before and after benidipine administration.
RESULTS
The antihypertensive effect of benidipine was evaluated in 15 patients and the safety in 16 patients. The blood pressure significantly reduced from 170+/-12mmHg/102+/-5mmHg to 137+/-15mmHg/86+/-8mmHg at 10-week administration of benidipine and the overall effective rate was 100%. Heart rate was not affected by benidipine. The slight increase of total protein, BUN, potassium, and glucose was observed at 10 weeks of benidipine administration. Four cases of headache and 1 case of frequent urination were observed and the medication was discontinued in one patient due to headache.
CONCLUSION
Benidipine proved effective and safe in the treatment of essential hypertension.

Keyword

Benidipine; Essential Hypertension; Ca(++)-Channel Blocker

MeSH Terms

Blood Pressure
Electrocardiography
Glucose
Headache
Heart Rate
Humans
Hypertension
Potassium
Thorax
Urination
Glucose
Potassium