Gut Liver.  2017 Sep;11(5):728-732. 10.5009/gnl16526.

Assessment of the Risk of Colorectal Cancer Survivors Developing a Second Primary Pancreatic Cancer

• Chung JW
• Chung MJ
• Bang S
• Park SW
• Song SY
• Chung JB
• Park JY

• KMID: 2389362
• DOI: http://doi.org/10.5009/gnl16526

Abstract

BACKGROUND/AIMS
We aimed to investigate the incidence of second primary pancreatic cancer (PC) after colorectal cancer (CRC) and to identify risk factors associated with subsequent PC.
METHODS
The observed incidence of a subsequent PC in patients with CRC was standardized using a population with CRC from the Korean Central Cancer Registry (KCCR). The expected incidence rate of PC was obtained by assuming that the select group experienced the same cancer incidence as the corresponding general population in the KCCR.
RESULTS
The registry included 4,822 patients with CRC aged 45 to 74 years, representing 16,725.1 person-years of follow-up. Thirteen patients (0.3%) were diagnosed with a subsequent PC, and the overall age-adjusted incidence of second primary PC was 269.6 per 100,000 cases. In contrast, the overall incidence of primary PC in the general population was 18.68 per 100,000 individuals. The standardized incidence ratio of subsequent PC was 14.44, which was significantly higher in patients with CRC than in the general population. Sex, diabetes mellitus, smoking, body mass index, and a history of receiving chemotherapy as a treatment for CRC did not increase the risk of subsequent development of PC.
CONCLUSIONS
The risk of a second primary PC was higher in patients with CRC. Further studies are needed to identify the risk factors and generate a screening strategy for cancer survivors.

Keyword

Pancreatic neoplasms; Colorectal neoplasms; Second primary neoplasm

MeSH Terms

Body Mass Index
Colorectal Neoplasms*
Diabetes Mellitus
Drug Therapy
Follow-Up Studies
Humans
Incidence
Mass Screening
Neoplasms, Second Primary
Pancreatic Neoplasms*
Risk Factors
Smoke
Smoking
Survivors*
Smoke