World J Mens Health.  2017 Aug;35(2):77-93. 10.5534/wjmh.2017.35.2.77.

Role of Antioxidants in Assisted Reproductive Techniques

• Agarwal A
• Majzoub A

• KMID: 2388443
• DOI: http://doi.org/10.5534/wjmh.2017.35.2.77

Abstract

Oxidative stress (OS) has been recognized as a significant cause of suboptimal assisted reproductive outcome. Many of the sperm preparation and manipulation procedures that are necessary in the in vitro environment can result in excessive production of reactive oxygen species (ROS) thereby exposing the gametes and growing embryos to significant oxidative damage. Antioxidants have long been utilized in the management of male subfertility as they can counterbalance the elevated levels of ROS inducing a high state of OS. Few studies have looked into the clinical effectiveness of antioxidants in patients undergoing assisted reproduction. While an overall favorable outcome has been perceived, the specific clinical indication and optimal antioxidant regimen remain unknown. The goal of our review is to explore the sources of ROS in the in vitro environment and provide a clinical scenario-based approach to identify the circumstances where antioxidant supplementation is most beneficial to enhance the outcome of assisted reproduction.

Keyword

Antioxidants; Oxidative stress; Reproductive techniques, assisted

MeSH Terms

Antioxidants*
Embryonic Structures
Germ Cells
Humans
In Vitro Techniques
Infertility, Male
Male
Oxidative Stress
Reactive Oxygen Species
Reproduction
Reproductive Techniques, Assisted*
Spermatozoa
Treatment Outcome
Antioxidants
Reactive Oxygen Species

Figure

• 

  Fig. 1 Sources of reactive oxygen species (ROS) in the assisted reproduction setting. IVF-ET: in vitro fertilization-embryo transfer. Data from Cleveland Clinic Foundation (CCF) with CCF's permission.

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