Clin Nutr Res.  2017 Apr;6(2):136-144. 10.7762/cnr.2017.6.2.136.

A Case Report of the Nutrition Support for a Patient with HELLP Syndrome

Affiliations
  • 1Department of Nutrition Care, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea. nutrpine@yuhs.ac
  • 2Department of Nutrition Services, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.
  • 3Department of Pharmacy, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.
  • 4Department of Food and Nutrition, Soongeui Women's College, Seoul 04628, Korea.
  • 5Department of Anesthesiology and Pain Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.

Abstract

A 30-year-old female patient, 18 weeks gestational age, with no prior medical history was admitted to hospital complaining severe right upper quadrant pain. The patient was admitted to intensive care unit (ICU) after emergency surgery to treat intraperitoneal hemorrhage caused by rupture of liver hematoma. Despite the absence of high blood pressure, the patient was diagnosed with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome on the basis of abnormal levels of blood aspartate aminotransferase/alanine aminotransferase, lactate dehydrogenase, total bilirubin, direct bilirubin, C-reactive protein (CRP) and platelet along with liver damage and proteinuria. While in ICU, the patient was given total parenteral nutrition (TPN) and enteral nutrition (EN) for -20 days because oral feeding was impractical. In the early stage, TPN supply was not sufficient to meet the elevated nutritional demand induced by disease and surgery. Nevertheless, continuous care of nutrition support team enabled satisfactory EN and, subsequently, oral feeding which led to improvement in patient outcome.

Keyword

HELLP syndrome; Nutrition support; Enteral nutrition; Parenteral nutrition

MeSH Terms

Adult
Aspartic Acid
Bilirubin
Blood Platelets
C-Reactive Protein
Emergencies
Enteral Nutrition
Female
Gestational Age
HELLP Syndrome*
Hematoma
Hemolysis
Hemorrhage
Humans
Hypertension
Intensive Care Units
L-Lactate Dehydrogenase
Liver
Parenteral Nutrition
Parenteral Nutrition, Total
Platelet Count
Pregnancy
Proteinuria
Rupture
Aspartic Acid
Bilirubin
C-Reactive Protein
L-Lactate Dehydrogenase

Figure

  • Figure 1 Progression of nutritional support and clinical aspects of the patient. HOD, hospital onset of day; NST consult, nutrition support team consult; NSVD, normal spontaneous vaginal delivery; TPN, total parenteral nutrition.

  • Figure 2 The amount of energy delivery during hospital stays. HOD, hospital onset of day.

  • Figure 3 The amount of protein delivery during hospital stays. HOD, hospital onset of day.

  • Figure 4 Changes in the cholesterol, albumin, and serum CRP concentration of the patient. CRP, C-reactive protein.


Reference

1. Lachmeijer AM, Arngrímsson R, Bastiaans EJ, Frigge ML, Pals G, Sigurdardóttir S, Stéfansson H, Pálsson B, Nicolae D, Kong A, Aarnoudse JG, Gulcher JR, Dekker GA, ten Kate LP, Stéfansson K. A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet. 2001; 9:758–764.
Article
2. Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol. 1982; 142:159–167.
Article
3. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol. 1990; 162:311–316.
Article
4. Sibai BM. Imitators of severe pre-eclampsia/eclampsia. Clin Perinatol. 2004; 31:835–852.
Article
5. Martin JN Jr, Blake PG, Perry KG Jr, McCaul JF, Hess LW, Martin RW. The natural history of HELLP syndrome: patterns of disease progression and regression. Am J Obstet Gynecol. 1991; 164:1500–1509.
Article
6. Martin JN Jr, Rinehart BK, May WL, Magann EF, Terrone DA, Blake PG. The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification. Am J Obstet Gynecol. 1999; 180:1373–1384.
Article
7. Geary M. The HELLP syndrome. Br J Obstet Gynaecol. 1997; 104:887–891.
Article
8. Aarnoudse JG, Houthoff HJ, Weits J, Vellenga E, Huisjes HJ. A syndrome of liver damage and intravascular coagulation in the last trimester of normotensive pregnancy. A clinical and histopathological study. Br J Obstet Gynaecol. 1986; 93:145–155.
Article
9. Pokharel SM, Chattopadhyay SK, Jaiswal R, Shakya P. HELLP syndrome--a pregnancy disorder with poor prognosis. Nepal Med Coll J. 2008; 10:260–263.
10. Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy Childbirth. 2009; 9:8.
Article
11. McWhirter JP, Pennington CR. Incidence and recognition of malnutrition in hospital. BMJ. 1994; 308:945–948.
Article
12. Ziegler TR. Parenteral nutrition in the critically ill patient. N Engl J Med. 2009; 361:1088–1097.
Article
13. Heyland DK, Montalvo M, MacDonald S, Keefe L, Su XY, Drover JW. Total parenteral nutrition in the surgical patient: a meta-analysis. Can J Surg. 2001; 44:102–111.
14. McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C; Society of Critical Care Medicine; American Society for Parenteral and Enteral Nutrition. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2016; 40:159–211.
Article
15. Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, Griffiths R, Kreyman G, Leverve X, Pichard C. ESPEN. ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr. 2009; 28:387–400.
Article
16. Manzanares W, Dhaliwal R, Jiang X, Murch L, Heyland DK. Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis. Crit Care. 2012; 16:R66.
Article
17. Mirtallo J, Canada T, Johnson D, Kumpf V, Petersen C, Sacks G, Seres D, Guenter P. Task Force for the Revision of Safe Practices for Parenteral Nutrition. Safe practices for parenteral nutrition. JPEN J Parenter Enteral Nutr. 2004; 28:S39–S70.
Article
Full Text Links
  • CNR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr