Korean J Helicobacter Up Gastrointest Res.
2017 Jun;17(2):79-82. 10.7704/kjhugr.2017.17.2.79.
Risk of Bacterial Infection from Proton Pump Inhibitor Use
- Affiliations
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- 1Department of Internal Medicine, Uijeongbu St. Mary Hospital, The Catholic University of Korea, Uijeongbu, Korea.
- 2Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
- 4Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. moonjs2@unitel.co.kr
- 5Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
- 6Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
- 7Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 2383585
- DOI: http://doi.org/10.7704/kjhugr.2017.17.2.79
Abstract
- Currently, proton pump inhibitors are used in a wide range of patients with gastroesophageal reflux disease, peptic ulcer, and upper gastrointestinal symptoms such as dyspepsia. In addition, the application of proton pump inhibitors for prevention of gastrointestinal complications induced by non-steroidal anti-inflammatory drugs is expected to increase their use in the future. The use of proton pump inhibitors promotes bacterial growth by reducing gastric acid concentration. If the acidity (pH) of the stomach fluid is lower than 4, most pathogens can be sterilized. However, patients who need to use a proton pump inhibitor should maintain a gastric acidity of at least 5 or 6, and can be at risk of infections such as pneumonia and Clostridium difficile infection. Several infectious diseases associated with the use of proton pump inhibitors were reviewed.
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