Ann Dermatol.  1999 Oct;11(4):292-296. 10.5021/ad.1999.11.4.292.

Angiocentric T cell Lymphoma associated with Epstein-Barr Virus

• Park JY
• Kim NI

• KMID: 2383045
• DOI: http://doi.org/10.5021/ad.1999.11.4.292

Abstract

Angiocentric T-cell lymphomas have been described as a distinctive clinicopathologic entity in the spectrum of peripheral T-cell lymphomas, with a prominent invasion of blood vessels by lymphomatous cells. In these conditions, the presence of Epstein-Barr virus (EBV) genomes has been demonstrated, suggesting that EBV might play a major role in their cause. Herein, we report a case of cutaneous angiocentric T cell lymphoma associated with the EBV. The patient was diagnosed with nasal angiocentric T cell lymphoma 5 months ago, and treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) combination chemotherapy. After three cycles of CHOP, skin lesions developed. A skin biopsy specimen showed an angiocentric and angioinvasive infiltrate containing some atypical lymphocytes. EBV encoded RNA (EBER) was demonstrated in lesional skin by in situ hybridization.

Keyword

Angiocentric T cell lymphoma; EBV

MeSH Terms

Biopsy
Blood Vessels
Cyclophosphamide
Doxorubicin
Drug Therapy, Combination
Genome
Herpesvirus 4, Human*
Humans
In Situ Hybridization
Lymphocytes
Lymphoma, T-Cell*
Lymphoma, T-Cell, Peripheral
Prednisolone
RNA
Skin
Vincristine
Cyclophosphamide
Doxorubicin
Prednisolone
RNA
Vincristine