Gut Liver.  2016 Jan;10(1):76-82. 10.5009/gnl14381.

Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms

• Baeg MK
• Choi MG
• Jung YD
• Ko SH
• Lim CH
• Kim HH
• Kim JS
• Cho YK
• Park JM
• Lee IS
• Kim SW

• KMID: 2382347
• DOI: http://doi.org/10.5009/gnl14381

Abstract

BACKGROUND/AIMS
Esophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors. We aimed to investigate whether the CRN risk is increased in ESCC patients.
METHODS
ESCC patients who underwent a colonoscopy within 1 year of diagnosis were retrospectively analyzed. Patients were matched 1:3 by age, gender, and body mass index to asymptomatic controls. CRN was defined as the histological confirmation of adenoma or adenocarcinoma. Advanced CRN was defined as any of the following: > or =3 adenomas, high-grade dysplasia, villous features, tumor > or =1 cm, or adenocarcinoma. The risk factors for both CRN and advanced CRN were evaluated by univariate and multivariate analyses.
RESULTS
Sixty ESCC patients were compared with 180 controls. The ESCC group had significantly higher numbers of CRNs (odds ratio [OR], 2.311; 95% confidence interval [CI], 1.265 to 4.220; p=0.006) and advanced CRNs (OR, 2.317; 95% CI, 1.185 to 4.530; p=0.013). Significant risk factors for both CRN and advanced CRN by multivariate analysis included ESCC (OR, 2.157, 95% CI, 1.106 to 4.070, p=0.024; and OR, 2.157, 95% CI, 1.045 to 4.454, p=0.038, respectively) and older age (OR, 1.068, 95% CI, 1.032 to 1.106, p<0.001; and OR, 1.065, 95% CI, 1.024 to 1.109, p=0.002, respectively).
CONCLUSIONS
The rates of CRN and advanced CRN are significantly increased in ESCC. Colonos-copy should be considered at ESCC diagnosis.

Keyword

Colorectal neoplasms; Esophageal neoplasms; Esophageal squamous cell carcinoma; Colonoscopy; Colorectal adenoma and carcinoma

MeSH Terms

Adenocarcinoma/diagnosis/*etiology
Adenoma/diagnosis/*etiology
Aged
Carcinoma, Squamous Cell/diagnosis/*etiology
Case-Control Studies
Colonoscopy
Colorectal Neoplasms/diagnosis/*etiology
Esophageal Neoplasms/diagnosis/*etiology
Female
Humans
Male
Middle Aged
Neoplasms, Multiple Primary/diagnosis/*etiology
Odds Ratio
Retrospective Studies
Risk Factors