Kidney Res Clin Pract.  2015 Mar;34(1):47-52. 10.1016/j.krcp.2015.01.002.

Genetic predisposition of donors affects the allograft outcome in kidney transplantation: Single-nucleotide polymorphism of aquaporin-11

• Park JI
• Yang SH
• Lee JP
• Yoo SH
• Kim YS

• KMID: 2381513
• DOI: http://doi.org/10.1016/j.krcp.2015.01.002

Abstract

BACKGROUND
Aquaporin-11 (AQP11) is a novel member of the aquaporin family. Disruption of the murine Aqp11 gene causes severe proximal tubular injury and renal failure. The rs2276415 (G>A) single-nucleotide polymorphism in the human AQP11 gene results in glycine to serine substitution in a functionally important domain. In this study, the role of the genetic predispositions of AQP11 rs2276415 (G>A) on renal allograft outcomes was evaluated.
METHODS
A total of 198 pairs of donors and recipients were enrolled in this study. Long-term graft survival was traced and clinical parameters that could have influenced graft outcome were collected through the electronic medical record system.
RESULTS
The genotype distribution and allele frequency of rs2276415 polymorphism were not different between donors and recipients. Despite similar allele frequencies between donors and recipients, the minor allele rs2276415 (GA+AA) of AQP11 from the donors, but not from the recipients, had a harmful effect on the graft survival compared with the wild-type donor (GG; P=0.029). This association was significant after adjusting for several risk factors including age, sex, human leukocyte antigen mismatch, donor type, hypertension, and diabetes mellitus (P=0.032).
CONCLUSION
A donor-derived, not recipient-derived, genetic AQP11 polymorphism has different effects on graft outcome. Thus, the genetic influence from donors should be carefully considered for proper management of allografts after kidney transplantation.

Keyword

Aquaporins; Kidney transplantation; Single nucleotide polymorphism

MeSH Terms

Alleles
Allografts*
Aquaporins
Diabetes Mellitus
Electronic Health Records
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Glycine
Graft Survival
Humans
Hypertension
Kidney Transplantation*
Leukocytes
Polymorphism, Single Nucleotide
Renal Insufficiency
Risk Factors
Serine
Tissue Donors*
Transplants
Aquaporins
Glycine
Serine