J Neurogastroenterol Motil.  2015 Apr;21(2):217-221. 10.5056/jnm14126.

In Vitro Effects of Rabeprazole on Human Pylorus Tone

• Yasar NF
• Polat E
• Duman M
• Dagdelen M
• Gunal MY
• Uzun O
• Akyuz C
• Peker KD
• Yol S

• KMID: 2381253
• DOI: http://doi.org/10.5056/jnm14126

Abstract

BACKGROUND/AIMS
It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle.
METHODS
Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and response to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled water was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10-6, 10-5, 10-4, and 10-3 M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured.
RESULTS
The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth intervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals.
CONCLUSIONS
In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.

Keyword

Muscle tonus; Proton pump inhibitors; Pylorus; Rabeprazole

MeSH Terms

Baths
Carbachol
Humans
Muscle Tonus
Muscle, Smooth
Muscles
Proton Pump Inhibitors
Pylorus*
Rabeprazole*
Relaxation
Stomach Neoplasms
Water
Carbachol
Proton Pump Inhibitors
Water