J Neurogastroenterol Motil.
2014 Jan;20(1):64-73.
Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group
- Affiliations
-
- 1Direccion de Investigacion, Hospital General de Mexico OD, Mexico City, Mexico. jclalvar@yahoo.com
- 2Medical Research Department, Takeda Mexico S.A. de C.V., Naucalpan, Edo. Mex, Mexico.
- 3The Lynn Health Science Institute, Oklahoma City, Oklahoma, USA.
- 4Instituto de Investigaciones Medico Biologicas, Universidad Veracruzana, Veracruz, Ver, Mexico.
- 5Departamento de Gastroenterologia, Hospital General de Occidente, SS, Zapopan, Jal., Mexico.
- 6Departamento de Endoscopia, Hospital de Alta Especialidad PEMEX Sur, Mexico City, Mexico.
- 7Departamento de Cirugia General y Gastroenterologia, Hospital Angeles del Pedregal, Mexico City, Mexico.
- 8Departamento de Endoscopia, Instituto Nacional de Cancerologia, Mexico City, Mexico.
- 9Departamento de Endoscopia, Hospital ABC, Mexico City, Mexico.
- 10Coordinacion de Investigacion en Salud, IMSS, Puebla, Pue. Mexico.
- 11Gastrolab S.A. de C.V., Clinical Research, Laboratorio de Fisiologia Digestiva, Guadalajara, Jalisco, Mexico.
- 12Direccion de Ensenanza, Fundacion Altius Internacional, Mexico City, Mexico.
- 13Global Medical Affairs, Takeda Pharmaceuticals International GmbH, Zurich, Switzerland.
- 14Division of Gastroenterology and Hepatology, Esophageal and Swallowing Center, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Abstract
- BACKGROUND/AIMS
To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms.
METHODS
Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the patient-completed ReQuest in Practice(TM) questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms.
RESULTS
Out of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P < 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks improved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduction on ReQuest in Practice(TM) dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated.
CONCLUSIONS
Pantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms including sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Radiologic studies on gastroesophageal reflux
- How Is the Autonomic Nerve Function Different Between Gastroesophageal Reflux Disease Alone and Gastroesophageal Reflux Disease With Diabetes Mellitus Neuropathy?
- Is Gastroesophageal Reflux Disease and Achalasia Coincident or Not?
- Upper Gastrointestinal Cancer and Reflux Disease
- Psychological Factors Influence the Symptoms of Gastroesophageal Reflux Disease
