J Cancer Prev.  2015 Sep;20(3):202-207. 10.15430/JCP.2015.20.3.202.

Antioxidative Activity of Onion Peel Extract in Obese Women: A Randomized, Double-blind, Placebo Controlled Study

• Kim KA
• Yim JE

• KMID: 2380871
• DOI: http://doi.org/10.15430/JCP.2015.20.3.202

Abstract

BACKGROUND
Quercetin, found abundantly in onion peel, has been known to have anticholesterol, antithrombotic and insulin-sensitizing properties. Here, we investigated the effect of quercetin-rich onion peel extract (OPE) on reactive oxygen species (ROS) production and antioxidative defense in obese woman.
METHODS
This study was randomized, double-blind, placebo controlled study. Thirty-seven healthy obese participants were randomly assigned that eighteen subjects received red soft capsuled OPE (100 mg/d, 50 mg bis in die), while the other nineteen subjects received same capsuled placebo for 12 weeks. ROS production and superoxide dismutase (SOD) activity in plasma were determined by using ROS and SOD assay kits, respectively.
RESULTS
Baseline characteristics of anthropometric indicators and blood metabolic profiles were not significantly different between the two groups. Compared with baseline values, OPE consumption significantly reduced waist and hip circumference. Plasma ROS level and SOD activity were decreased in both placebo and OPE groups compared with baseline values. However, plasma ROS level in OPE group was significantly lower than in placebo group while plasma SOD activity in OPE group was significantly higher than in placebo group after 12 weeks of consumption.
CONCLUSIONS
These findings indicate that OPE consumption may exert antioxidative effect by preventing the decrease of SOD activity as well as the production of ROS in obese women.

Keyword

Onion peel extract; Quercetin; Reactive oxygen species; Superoxide dismutase

MeSH Terms

Female
Hip
Humans
Metabolome
Onions*
Plasma
Quercetin
Reactive Oxygen Species
Superoxide Dismutase
Quercetin
Reactive Oxygen Species
Superoxide Dismutase