Nutr Res Pract.  2013 Oct;7(5):373-379. 10.4162/nrp.2013.7.5.373.

Effect of onion peel extract supplementation on the lipid profile and antioxidative status of healthy young women: a randomized, placebo-controlled, double-blind, crossover trial

Affiliations
  • 1Department of Food and Nutrition, Kyungnam University, 449 Woryeong-dong, Masanhappo-gu, Changwon-si, Gyeongnam 631-701, Korea. pej@kyungnam.ac.kr
  • 2Department Food and Nutrition, Changwon National University, Changwon, Gyeongnam 641-773, Korea.

Abstract

The consumption of fruits and vegetables that have high polyphenol content has been previously associated with a reduced risk for cardiovascular disease. We investigated the effects of onion peel extract on plasma total antioxidant capacity, lipid peroxidation, and leukocyte DNA damage. This study was a randomized, double-blind, placebo-controlled, crossover trial. Healthy female subjects received either onion peel extract or placebo (dextrin) for two weeks, underwent a 1-week washout period, and then received the other treatment for an additional two weeks. After two weeks of onion peel extract supplementation, the total cholesterol level, low-density lipoprotein cholesterol level, and atherogenic index significantly decreased (P < 0.05). No changes were observed in activities of erythrocyte antioxidant enzymes or levels of lipid peroxidation markers following onion peel extract supplementation. Additionally, no significant difference was found in plasma antioxidant vitamin (retinol, tocopherols, carotenoids, and coenzyme Q10) levels or ex vivo H2O2-provoked oxidative DNA damage after onion peel extract supplementation. The present interventional study provides evidence of the health benefits of onion peel extract and demonstrates its effects in modulating lipid profiles in healthy young Korean women.

Keyword

Onion peel extract; lipid profile; antioxidant status; DNA damage; healthy young women

MeSH Terms

Cardiovascular Diseases
Carotenoids
Cholesterol
DNA Damage
Erythrocytes
Female
Fruit
Humans
Insurance Benefits
Leukocytes
Lipid Peroxidation
Lipoproteins
Onions
Plasma
Tocopherols
Vegetables
Vitamins
Carotenoids
Cholesterol
Lipoproteins
Tocopherols
Vitamins

Figure

  • Fig. 1 Changes of serum total cholesterol and atherogenic index before and after trial. The P values indicate the significant difference between week 0 and week 2 within the group by paired t-test.


Cited by  2 articles

Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study
Ji-Sook Lee, Yong-Jun Cha, Kyung-Hea Lee, Jung-Eun Yim
Nutr Res Pract. 2016;10(2):175-181.    doi: 10.4162/nrp.2016.10.2.175.

The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women
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