Korean J Anesthesiol.  2016 Oct;69(5):468-473. 10.4097/kjae.2016.69.5.468.

Pretreatmet with 5% lidocaine patch reduces cannula-induced and propofol-induced pain: a randomized, double-blind, placebo-controlled study

• Hong JM
• Lee HJ
• Cho AR
• Baik JS
• Lee DW
• Ji YT
• Yoo KC
• Kim HK

• KMID: 2379236
• DOI: http://doi.org/10.4097/kjae.2016.69.5.468

Abstract

BACKGROUND
The purpose of this study was to determine the efficacy of 5% lidocaine patch in reducing propofol-induced pain and cannula-induced pain.
METHODS
In a randomized, double-blind study, 126 patients were divided into one of three groups: pretreatment with a 5% lidocaine patch (Lidotop®) and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group A); pretreatment with a placebo patch and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group B); or pretreatment with a placebo patch and premixed 2 ml of 2% lidocaine (40 mg) with 1.5 mg/kg of 1% propofol (Group C) for induction of anesthesia. Pain severity was evaluated on a four-point verbal rating scale during intravenous cannulation, propofol injection, and 24 h after the operation (recall).
RESULTS
Eighteen patients (47.4%) in Group A complained of cannula-induced pain compared with 35 (94.6%) in Group B and 36 (94.7%) in Group C (P < 0.001). Group A patients showed significantly lower incidence of propofol-induced pain and recall of propofol-induced pain compared with Group B (P < 0.001 and P = 0.01), whereas there was no difference compared with Group C.
CONCLUSIONS
Preoperative transdermal administration of 5% lidocaine patch is an effective and simple method in reducing propofol-induced pain as well as cannula-induced pain.

Keyword

Cutaneous administration; Lidocaine; Pain; Propofol

MeSH Terms

Administration, Cutaneous
Anesthesia
Catheterization
Double-Blind Method
Humans
Incidence
Lidocaine*
Methods
Propofol
Lidocaine
Propofol