Obstet Gynecol Sci.  2017 May;60(3):260-265. 10.5468/ogs.2017.60.3.260.

Is massive proteinuria associated with maternal and fetal morbidities in preeclampsia?

• Kim MJ
• Kim YN
• Jung EJ
• Jang HR
• Byun JM
• Jeong DH
• Sung MS
• Lee KB
• Kim KT

• KMID: 2378587
• DOI: http://doi.org/10.5468/ogs.2017.60.3.260

Abstract

OBJECTIVE
The aim of this study was to investigate whether massive proteinuria in preeclampsia is associated with maternal and fetal complications.
METHODS
We retrospectively analyzed the clinical records of 233 patients who were diagnosed with preeclampsia. We divided the preeclamptic patients into three groups based on the amount of proteinuria: massive (≥5 g/24 hr), moderate (2 to 5 g/24 hr) and mild (<2 g/24 hr) proteinuria group. We analyzed the clinical characteristics and maternal and neonatal complications among three groups.
RESULTS
Gestational age at diagnosis and delivery were lower in women with massive and moderate proteinuria group than women with mild proteinuria group (31.5±3.1 vs. 32.3±3.6 vs. 34.0±3.5 weeks, P<0.001 for gestational weeks at diagnosis; 34.6±3.6 vs. 35.1±4.1 vs. 36.9±4.0 weeks, P=0.001 for gestational age at delivery). In maternal complications, the incidences of pleural effusion and retinal detachment were significantly different among three groups (29.9% vs. 22.4% vs. 9.0%, P=0.004 for pleural effusion; 11.5% vs. 3.0% vs. 1.3%, P=0.009 for retinal detachment). Creatinine levels were higher and albumin levels were lower in the massive proteinuria group than in the moderate and mild groups. However, other maternal and neonatal complications were not significantly different among three groups.
CONCLUSION
Massive proteinuria might be associated with renal albumin excretion-related morbidity, such as pleural effusion, retinal detachment, and low serum albumin levels. Furthermore, it was associated with early-onset preeclampsia and early delivery.

Keyword

Morbidity; Pre-eclampsia; Pregnancy complications; Proteinuria

MeSH Terms

Creatinine
Diagnosis
Female
Gestational Age
Humans
Incidence
Pleural Effusion
Pre-Eclampsia*
Pregnancy Complications
Proteinuria*
Retinal Detachment
Retinaldehyde
Retrospective Studies
Serum Albumin
Creatinine
Retinaldehyde
Serum Albumin

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