Korean J Intern Med.  2017 Nov;32(6):1062-1068. 10.3904/kjim.2016.025.

Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study

• Bae EH
• Kim JW
• Choi HS
• Ma SK
• Kim SW

• KMID: 2396766
• DOI: http://doi.org/10.3904/kjim.2016.025

Abstract

BACKGROUND/AIMS
Proteinuria is associated with hypertension and preeclampsia in pregnancy. However, the impact of random urine proteinuria on fetal and maternal outcomes has not been established. We investigated the influence of random urine proteinuria on the clinical outcomes of pregnancy.
METHODS
From January 2008 to December 2010, 2,822 patients were retrospectively studied. A total of 536 pregnant women with proteinuria in random urine and matched controls without proteinuria via propensity score matching were analyzed. Proteinuria was checked by the dipstick method.
RESULTS
The patients' mean age was 33.0 ± 4.7 years, and the mean gestational age was 235.6 ± 50.6 days on admission. The prevalence of hypertension and chronic kidney disease was 2.4% (n = 67) and 1.0% (n = 29), respectively. Women with random urine proteinuria showed higher blood urea nitrogen levels and a higher incidence of hematuria. These women also had a higher incidence of preeclampsia, preterm labor, premature rupture of membranes, and intrauterine growth restriction. Proteinuria was strongly correlated with preeclampsia in both propensity score matching (p < 0.001, r = 0.783) and unmatched whole samples (p < 0.001, r = 0.851).
CONCLUSIONS
These findings suggest that random urine proteinuria is associated with preeclampsia, preterm labor, premature rupture of membrane, and intrauterine growth restriction.

Keyword

Proteinuria; Dipstick; Pre-eclampsia; Random urine; Obstetric labor, premature

MeSH Terms

Blood Urea Nitrogen
Case-Control Studies*
Female
Gestational Age
Hematuria
Humans
Hypertension
Incidence
Membranes
Methods
Obstetric Labor, Premature
Pre-Eclampsia
Pregnancy*
Pregnant Women
Prevalence
Propensity Score
Proteinuria*
Renal Insufficiency, Chronic
Retrospective Studies*
Rupture