Clin Nutr Res.  2017 Jan;6(1):38-46. 10.7762/cnr.2017.6.1.38.

Association between Nutrient Intake and Metabolic Syndrome in Patients with Colorectal Cancer

• Lim HS
• Shin EJ
• Yeom JW
• Park YH
• Kim SK

• KMID: 2377800
• DOI: http://doi.org/10.7762/cnr.2017.6.1.38

Abstract

The purpose of this study was to investigate the difference of nutritional status according to metabolic syndrome in colorectal cancer patients. The subjects were divided into 2 groups (metabolic syndrome group and normal group) according to the presence or absence of metabolic syndrome in 143 patients diagnosed with colorectal cancer, and their lifestyle and nutritional status were analyzed. Recall method was used for the dietary survey, and metabolic syndrome was defined as the presence of 3 or more of waist circumference, fasting blood glucose, triglyceride, high-density lipoprotein (HDL)-cholesterol, and blood pressure. This study showed that the metabolic syndrome group had a low age, a high body mass index (BMI), and a high drinking rate. The intake of energy, protein, fat, calcium, and phosphorus was significantly higher in the metabolic syndrome group than in the normal group, and the intake of β-carotene, vitamin C, and folic acid was significantly low. The intake of cholesterol, fatty acid, saturated fatty acid, and polyunsaturated fatty acid was also higher in the metabolic syndrome group. Higher BMI, alcohol consumption, intake of fat, total fatty acid or saturated fatty acid increased the risk of metabolic syndrome, but fiber, vitamin C, or folic acid intake lowered the risk.Weight management and balanced nutritional intake should be emphasized to prevent metabolic syndrome and to improve the condition in patients with colorectal cancer.

Keyword

Colorectal cancer; Metabolic syndrome; Nutritient intake; Diet; Lifestyle

MeSH Terms

Alcohol Drinking
Ascorbic Acid
Blood Glucose
Blood Pressure
Body Mass Index
Calcium
Cholesterol
Colorectal Neoplasms*
Diet
Drinking
Fasting
Folic Acid
Humans
Life Style
Lipoproteins
Methods
Nutritional Status
Phosphorus
Triglycerides
Waist Circumference
Ascorbic Acid
Blood Glucose
Calcium
Cholesterol
Folic Acid
Lipoproteins
Phosphorus

Reference

1. Gong YH, Yoon SJ, Jo MW, Kim A, Kim YA, Yoon J, Seo H, Kim D. The burden of cancer in Korea during 2012: findings from a prevalence-based approach. J Korean Med Sci. 2016; 31:Suppl 2. S168–77.

2. Richardson A, Hayes J, Frampton C, Potter J. Modifiable lifestyle factors that could reduce the incidence of colorectal cancer in New Zealand. N Z Med J. 2016; 129:13–20.

3. Tuan J, Chen YX. Dietary and lifestyle factors associated with colorectal cancer risk and interactions with microbiota: fiber, red or processed meat and alcoholic drinks. Gastrointest Tumors. 2016; 3:17–24.

4. Aran V, Victorino AP, Thuler LC, Ferreira CG. Colorectal cancer: epidemiology, disease mechanisms and interventions to reduce onset and mortality. Clin Colorectal Cancer. 2016; 15:195–203.

5. O’Neill AM, Burrington CM, Gillaspie EA, Lynch DT, Horsman MJ, Greene MW. High-fat Western diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer. Nutr Res. 2016; 36:1325–1334.

6. Belcheva A, Martin A. Gut microbiota and colon cancer: the carbohydrate link. Mol Cell Oncol. 2014; 2:e969630.

7. Djuric Z, Severson RK, Kato I. Association of dietary quercetin with reduced risk of proximal colon cancer. Nutr Cancer. 2012; 64:351–360.

8. Crockett SD, Long MD, Dellon ES, Martin CF, Galanko JA, Sandler RS. Inverse relationship between moderate alcohol intake and rectal cancer: analysis of the North Carolina Colon Cancer Study. Dis Colon Rectum. 2011; 54:887–894.

9. Zelenskiy S, Thompson CL, Tucker TC, Li L. High dietary glycemic load is associated with increased risk of colon cancer. Nutr Cancer. 2014; 66:362–368.

10. Morimoto LM, Newcomb PA, Ulrich CM, Bostick RM, Lais CJ, Potter JD. Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol Biomarkers Prev. 2002; 11:1012–1018.

11. Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med. 2000; 343:169–174.

12. Wang YY, Lin SY, Lai WA, Liu PH, Sheu WH. Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol. 2005; 20:1410–1415.

13. Schoen RE, Weissfeld JL, Kuller LH, Thaete FL, Evans RW, Hayes RB, Rosen CJ. Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology. 2005; 129:464–475.

14. Otake S, Takeda H, Suzuki Y, Fukui T, Watanabe S, Ishihama K, Saito T, Togashi H, Nakamura T, Matsuzawa Y, Kawata S. Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res. 2005; 11:3642–3646.

15. Leisegang K, Bouic PJ, Henkel RR. Metabolic syndrome is associated with increased seminal inflammatory cytokines and reproductive dysfunction in a case-controlled male cohort. Am J Reprod Immunol. 2016; 76:155–163.

16. Suchanek S, Grega T, Ngo O, Vojtechova G, Majek O, Minarikova P, Brogyuk N, Bunganic B, Seifert B, Dusek L, Zavoral M. How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia? World J Gastroenterol. 2016; 22:8103–8111.

17. You J, Liu WY, Zhu GQ, Wang OC, Ma RM, Huang GQ, Shi KQ, Guo GL, Braddock M, Zheng MH. Metabolic syndrome contributes to an increased recurrence risk of non-metastatic colorectal cancer. Oncotarget. 2015; 6:19880–19890.

18. Andersen CJ, Murphy KE, Fernandez ML. Impact of obesity and metabolic syndrome on immunity. Adv Nutr. 2016; 7:66–75.

19. Bird CL, Ingles SA, Frankl HD, Lee ER, Longnecker MP, Haile RW. Serum lipids and adenomas of the left colon and rectum. Cancer Epidemiol Biomarkers Prev. 1996; 5:607–612.

20. Kono S, Handa K, Hayabuchi H, Kiyohara C, Inoue H, Marugame T, Shinomiya S, Hamada H, Onuma K, Koga H. Obesity, weight gain and risk of colon adenomas in Japanese men. Jpn J Cancer Res. 1999; 90:805–811.

21. Dixon LB, Balder HF, Virtanen MJ, Rashidkhani B, Männistö S, Krogh V, van Den Brandt PA, Hartman AM, Pietinen P, Tan F, Virtamo J, Wolk A, Goldbohm RA. Dietary patterns associated with colon and rectal cancer: results from the Dietary Patterns and Cancer (DIETSCAN) Project. Am J Clin Nutr. 2004; 80:1003–1011.

22. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F; American Heart Association. National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005; 112:2735–2752.

23. Freire RD, Cardoso MA, Gimeno SG, Ferreira SR; Japanese-Brazilian Diabetes Study Group. Dietary fat is associated with metabolic syndrome in Japanese Brazilians. Diabetes Care. 2005; 28:1779–1785.

24. Liu S, Manson JE. Dietary carbohydrates, physical inactivity, obesity, and the ‘metabolic syndrome’ as predictors of coronary heart disease. Curr Opin Lipidol. 2001; 12:395–404.

25. Freire RD, Cardoso MA, Gimeno SG, Ferreira SR; Japanese-Brazilian Diabetes Study Group. Dietary fat is associated with metabolic syndrome in Japanese Brazilians. Diabetes Care. 2005; 28:1779–1785.