Ann Lab Med.  2016 Sep;36(5):494-497. 10.3343/alm.2016.36.5.494.

Acute Myeloid Leukemia With MLL Rearrangement and CD4+/CD56+ Expression can be Misdiagnosed as Blastic Plasmacytoid Dendritic Cell Neoplasm: Two Case Reports

• Lee JM
• Kim IS
• Lee JN
• Park SH
• Kim HH
• Chang CL
• Lee EY
• Kim HR
• Oh SH
• Song SA

• KMID: 2373582
• DOI: http://doi.org/10.3343/alm.2016.36.5.494

Abstract

No abstract available.

MeSH Terms

Adult
Antigens, CD4/*metabolism
Antigens, CD56/*metabolism
Bone Marrow/metabolism/pathology
Dendritic Cells/cytology/*metabolism
Diagnostic Errors
Exons
Female
Flow Cytometry
Gene Rearrangement
Hematologic Neoplasms/diagnosis
Histone-Lysine N-Methyltransferase/genetics
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute/*diagnosis
Male
Middle Aged
Myeloid-Lymphoid Leukemia Protein/genetics
Real-Time Polymerase Chain Reaction
Sequence Analysis, DNA
Transcription Factors/genetics
Translocation, Genetic
Antigens, CD4
Antigens, CD56
Histone-Lysine N-Methyltransferase
Myeloid-Lymphoid Leukemia Protein
Transcription Factors

Figure

• 

  Fig. 1 Morphological features, flow cytometric analysis, immunohistochemical stain, and genetic study of the two cases of CD4+/CD56+AML. (A) Plasmoblast-like neoplastic cells in the first case (Wright Giemsa stain, 400×, Bone marrow); (B) Immunophenotyping features with CD56 and CD4 coexpression in the first case; (C) Skin biopsy showing diffuse infiltration of medium- to large-sized agranular blastic cells into the dermis in the first case (Hematoxylin and Eosin stain, 100×, Skin lesion); (D) The MLL-MLLT10 rearrangement confirmed by direct sequencing in the first case; (E) Plasmacytoid cells in the second case (Wright Giemsa stain; ×400, Bone marrow); and (F) The immunophenotyping features with CD4 and CD56 coexpression in the second case.

Reference

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