Korean J Gastroenterol.  2015 Feb;65(2):127-131. 10.4166/kjg.2015.65.2.127.

Appendiceal Neuroendocrine Tumor with Lymph Node Metastasis in a Teenager

• Kim KY
• Park WC

• KMID: 2373195
• DOI: http://doi.org/10.4166/kjg.2015.65.2.127

Abstract

Neuroendocrine tumor (NET) is a cancer-like tumor that occurs mostly in the gastrointestinal system. Within the gastrointestinal tract, NET most commonly occurs in the rectum whereas appendix is very rarely involved. In most cases of appendiceal NET, it is found at a relatively early stage compared to other NETs because appendiceal NET frequently presents with acute appendicitis because appendiceal NET frequently presents with acute appendicitis even when the size is smaller than 1 cm. Therefore, it is very rare for lymph node metastasis to occur in a young adult. Herein, we report a rare case of grade 1 appendiceal NET with lymph node metastasis which developed in a teenage male.

Keyword

Appendiceal neoplasms; Neuroendocrine tumor; Carcinoid tumor

MeSH Terms

Adolescent
Appendiceal Neoplasms/*diagnosis/pathology/surgery
Carcinoid Tumor/diagnosis/pathology
Colectomy
Colonoscopy
Humans
Lymphatic Metastasis
Male
Neuroendocrine Tumors/*diagnosis/pathology
Tomography, X-Ray Computed

Figure

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  Fig. 1. CT shows dilated appendix, which measures up to 2 cm in diameter (arrow), with proximal appendicolith.

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  Fig. 2. Gross findings of the resected appendix. No definite tumor is observed on the specimen.

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  Fig. 3. Microscopic findings. On histologic examination, the appendiceal lesion is a Grade 1 neuroendocrine tumor with no lymphova-scular invasion or cellular atypism. Mitotic count is lower than 2/10 HPF (H&E, ×100).

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  Fig. 4. Colonoscopy finding shows a normal appearing appendiceal orifice except for mild mucosal inflammation.

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  Fig. 5. Gross specimen obtained after right hemicolectomy.

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  Fig. 6. Microcopic finding of lymph node (H&E,×200).

Reference

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