Korean J Gastrointest Endosc.  2010 Aug;41(2):94-97.

Metastatic Large Cell Neuroendocrine Carcinoma Combined with Gastric Adenocarcinoma

• Cho KH
• Chang YW
• Sohn SD
• Hwangbo Y
• Shim J
• Jang JY
• Kim HJ
• Kim BH

Abstract

A 67 year-old man was admitted due to findings that were suspicious for malignancy on gastroscopy at a primary clinic. We also performed gastroscopy and this showed the presence of a 3 cm sized nodular elevated lesion at the angle of the stomach. A biopsy demonstrated the presence of adenocarcinoma of the stomach. A distal gastrectomy with D2 lymph node dissection was performed and the microscopic features of the resected specimen confirmed the diagnosis of adenocarcinoma of the stomach and also metastatic large cell neuroendocrine carcinoma of lymph nodes of an unknown primary origin. Although double primary gastric adenocarcinoma and gastric neuroendocrine tumor with regional lymph node metastasis has been seldom reported, a double primary carcinoma of gastric adenocarcinoma and metastatic large cell neuroendocrine carcinoma of lymph nodes has seldom been reported. We report on this unusual case along with a review of the relevant medical literature.

Keyword

Stomach adenocarcinoma; Neuroendocrine tumor

MeSH Terms

Adenocarcinoma
Biopsy
Carcinoma, Neuroendocrine
Gastrectomy
Gastroscopy
Lymph Node Excision
Lymph Nodes
Neoplasm Metastasis
Neuroendocrine Tumors
Stomach