J Korean Soc Radiol.  2010 Sep;63(3):239-243. 10.3348/jksr.2010.63.3.239.

Gastric Collision Tumor Consisting of Mucinous Carcinoma and Large Cell Neuroendocrine Carcinoma: A Case Report

• Kang SM
• Lee YR
• Han EM
• Yeon JW
• Yoo JY
• Choi JM
• Sim JY

• KMID: 2097899
• DOI: http://doi.org/10.3348/jksr.2010.63.3.239

Abstract

The concurrence of two different pathological tumors of the stomach is infrequent. Even rarer is a gastric collision tumor of both tumor types. Although there have been a few reported cases of gastric collision tumors that consisted of an adenocarcinoma and neuroendocrine carcinoma, to the best of our knowledge, there is no documented case report of a gastric collision tumor consisting of a mucinous carcinoma and large cell neuroendocrine carcinoma. We report a case of gastric collision tumor, consisting of a mucinous carcinoma and large cell neuroendocrine carcinoma that presented as abdominal discomfort in a 64-year-old man. This finding draws attention to the related findings from previous studies on gastric collision tumors.

MeSH Terms

Adenocarcinoma
Adenocarcinoma, Mucinous
Carcinoma, Neuroendocrine
Humans
Middle Aged
Mucins
Neoplasms, Multiple Primary
Stomach
Stomach Neoplasms
Tomography, X-Ray Computed
Mucins

Figure

• 

  Fig. 1 A 64-year-old man with a mucinous carcinoma and neuroendocrine carcinoma of the stomach. A. Contrast-enhanced coronal CT scan obtained during the portal venous phase shows focal wall thickening (white arrows) at the antrum. Note the border between the mucinous carcinoma (white asterisk) and neuroendocrine carcinoma (black asterisk). B. Contrast-enhanced axial CT scan obtained during the delayed phase shows focal wall thickening (white arrows) at anterior and posterior wall of the proximal antrum, particularly in the low-attenuating middle or outer layer, with more than 50% preservation of the thin high-attenuating inner layer. The layered enhancement pattern is shown. C. Contrast-enhanced axial CT scan obtained during the delayed phase shows well-enhancing, focal wall thickening (white arrows) with depression (black arrows) at anterior and posterior wall of the distal antrum. The homogeneous enhancement pattern is shown. D. Gross photography shows a large ulceroinfiltrative mass (Borrmann type 3) in antrum. Two distinct lesions were identified. One is the gelatinous and glistening mass (M) at lesser curvature, anterior and posterior wall of the proximal antrum, and the other is the firm mass (N) at greater curvature, anterior and posterior wall of the distal antrum. E. Microscopically, the tumors are composed of two distinct neoplastic cell component. Mucinous carcinoma shows the mucinous lakes containing floating cell clusters, and neuroendocrine carcinoma shows the tumor nest with central necrosis (data not shown). There is a no admixture at the border between the neuroendocrine carcinoma (N) and mucinous carcinoma (M) (H & E; ×12.5).

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