Korean J Dermatol.  2017 Mar;55(3):191-194.

A Case of Hyperpigmented Mycosis Fungoides with CD8 Positive Cells

• Kim HJ
• Shim CY
• Lee SY
• Park YL
• Lee JS
• Whang KU

Abstract

Mycosis fungoides (MF) represents the prototype of cutaneous T-cell lymphoma, which is defined as clonal expansion of skin-homing T lymphocytes. The natural history of MF is characterized by an indolent progression through patch, plaque, tumor, and visceral stages; however, this progression is not necessarily seen in all patients. Classically, the atypical lymphocytes in MF are CD3/CD4 positive with a loss of CD7. However, fewer than 5% of cases of MF present with a cytotoxic/suppressor CD8 positive phenotype, which presents with a variety of clinical features, including granulomatous, folliculotropic, poikilodermatous, hypopigmented, and hyperpigmented MF. Different immunophenotypic variants have been reported in MF but seem to lack any specific behavior and prognosis. Herein, we report a rare case of hyperpigmented MF with CD8 positive cells.

Keyword

CD8 positive; Hyperpigmentation; Mycosis fungoides

MeSH Terms

Humans
Hyperpigmentation
Lymphocytes
Lymphoma, T-Cell, Cutaneous
Mycosis Fungoides*
Natural History
Phenotype
Prognosis
T-Lymphocytes